The current research was conducted to examine the effect of Artemisia dracunculus (AD) extract on growth performance, haemato‐immunological, biochemical parameters, and mucosal immunity in the rainbow trout (Oncorhynchus mykiss). The fish were fed with a diet supplemented with 0 (control), 1%, 2% and 3% AD for 8 weeks. The findings indicated that in all groups fed AD, especially at the 2% level, the growth parameters and survival rate significantly increased compared with the control group. Blood biochemical parameters, creatinine, glucose, lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and triglyceride were decreased significantly in AD‐treated groups. Total serum protein (TSP) levels, lysozyme (LYZ) and respiratory burst activities (RBA) were increased in the fish fed with AD. TSP levels, ALP and protease (PA) activities in the mucus were significantly increased following fish fed with AD. Increased in the total immunoglobulins (Ig) and superoxide dismutase (SOD) activity were observed in the fish fed with 3% AD. Fish fed with 2% AD showed the highest levels of alternative complement (ACH50) significantly. In addition, the mucus bactericidal activity was significantly increased in some treatments fed AD diet against Lactococcus garvieae and Aeromonas hydrophila. After infection with Yersinia ruckeri, there was a reduction in the mortality rate in the AD‐fed groups compared with the control group. Thus, it can be concluded that diets supplemented with AD can significantly impact diverse physiological parameters in fish, improving their growth performance, blood biochemical parameters and immune response.

中文翻译：

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膳食补充剂金蒿提取物对虹鳟鱼（Oncorhynchus mykiss）的血液免疫，生化反应和生长性能的影响

目前的研究被进行以检查的效果龙蒿（AD）提取物上生长性能，血象免疫学，生物化学参数，并在虹鳟鱼的粘膜免疫（虹鳟）。给鱼饲喂补充0（对照），1％，2％和3％AD的饮食，持续8周。研究结果表明，所有进食AD的组，尤其是2％水平的AD组，其生长参数和存活率均显着高于对照组。在AD治疗组中，血液生化参数，肌酐，葡萄糖，乳酸脱氢酶（LDH），天冬氨酸转氨酶（AST），碱性磷酸酶（ALP）和甘油三酸酯显着降低。用AD饲喂的鱼的总血清蛋白（TSP）水平，溶菌酶（LYZ）和呼吸爆发活性（RBA）增加。鱼饲喂AD后，粘液中的TSP水平，ALP和蛋白酶（PA）活性显着增加。在饲喂3％AD的鱼中观察到总免疫球蛋白（Ig）和超氧化物歧化酶（SOD）活性增加。饲喂2％AD的鱼的替代补体（ACH50）含量最高。此外，在某些饮食中，AD饮食对小鼠的粘液杀菌活性显着提高。乳球菌和嗜水气单胞菌。与空白对照组相比，AD喂养组的鼠疫耶尔森氏菌感染后死亡率降低。因此，可以得出结论，补充AD的饮食可以显着影响鱼类的各种生理参数，从而改善其生长性能，血液生化参数和免疫反应。