Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial,Muscle & Nerve

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Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial
Muscle & Nerve ( IF 2.8 ) Pub Date : 2020-12-19 , DOI: 10.1002/mus.27146
Michael D Weiss ₁ , Eric A Macklin ₂ , Courtney E McIlduff ₃ , Steve Vucic ₄ , Brian J Wainger ₅ , Matthew C Kiernan ₄ , Stephen A Goutman ₆ , Namita A Goyal ₇ , Seward B Rutkove ₃ , Shafeeq S Ladha ₈ , I-Hweii Amy Chen ₉ , Matthew B Harms ₁₀ , Thomas H Brannagan ₁₀ , David Lacomis ₁₁ , Sasha Zivkovic ₁₁ , Maxwell Ma ₁ , Leo H Wang ₁ , Zachary Simmons ₁₂ , Michael H Rivner ₁₃ , Jeremy M Shefner ₈ , Merit E Cudkowicz ₅ , Nazem Atassi ₅ ,

Affiliation

Department of Neurology, University of Washington, Seattle, Washington, USA.
Department of Medicine, Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Department of Neurology, Royal Prince Alfred Hospital; and the Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Department of Neurology, University of California, Irvine, California, USA.
Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
Department of Neurology, Columbia University, New York, New York, USA.
Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Neurology, Penn State University, Hershey, Pennsylvania, USA.
Department of Neurology, Augusta University, Augusta, Georgia, USA.

To collect preliminary data on the effects of mexiletine on cortical and axonal hyperexcitability in sporadic amyotrophic lateral sclerosis (ALS) in a phase 2 double‐blind randomized controlled trial.

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