Polyoxometalates (POMs) have shown remarkable antitumor activity. However, the utilization of POMs is limited due to its poor water solubility, low bioavailability, thermodynamics and kinetic instability at physiological pH in water. In order to overcome these drawbacks, POMs with antitumor activity, [Na₁₀(H₂W₁₂O₄₂)]·26H₂O and [Hbiz]₅[HMo₅P₂O₂₃]·5H₂O, were encapsulated within solid lipid nanoparticles (abbreviated as NaW₁₂-SLNs and P₂Mo₅-SLNs, respectively), which have been prepared and structurally characterized by Fourier transform infrared (FT–IR) spectroscopy, UV–Vis spectroscopy, X-ray diffraction (XRD), dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images. The results show that POMs retain its parent structure after entrapped by SLNs. The in vitro antitumor activity of NaW₁₂ and P₂Mo₅ in its free and nano-encapsulated forms was investigated using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetra-zolium bromide (MTT) assay that was carried out on three types of human cancer cells, HeLa, HepG2 and SHY5Y. The results represent the enhancement of antitumor activity of POMs due to its encapsulation in SLNs. Moreover, the interactions of two types POMs towards ctDNA and bovine serum albumin (BSA) have been illustrated by electron absorption spectroscopy.

多金属氧酸盐（POM）已显示出显着的抗肿瘤活性。但是，由于POM的水溶性差，生物利用度低，在水中的生理pH值下的热力学和动力学不稳定，因此其使用受到限制。为了克服这些缺点，将具有抗肿瘤活性的POM [Na ₁₀（H ₂ W ₁₂ O ₄₂）]·26H ₂ O和[Hbiz] ₅ [HMo ₅ P ₂ O ₂₃ ]·5H ₂ O封装在固体中脂质纳米颗粒（缩写为NaW ₁₂ -SLNs和P ₂ Mo ₅-SLNs），分别通过傅立叶变换红外（FT-IR）光谱，UV-Vis光谱，X射线衍射（XRD），动态光散射（DLS），扫描电子显微镜（SEM）进行了制备并在结构上进行了表征和透射电子显微镜（TEM）图像。结果表明，POM被SLN包裹后仍保留其母体结构。在体外NAW的抗肿瘤活性₁₂和P ₂沫₅使用3- [4,5-二甲基噻唑-2-基] -2,5-二苯基-四唑溴化物（MTT）分析了三种形式的游离形式和纳米囊形式的化合物细胞，HeLa，HepG2和SHY5Y。结果表示由于将其封装在SLN中，增强了POM的抗肿瘤活性。此外，两种类型的POM对ctDNA和牛血清白蛋白（BSA）的相互作用已通过电子吸收光谱法进行了说明。