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Genome-wide Signatures of Early-Life Stress: Influence of Sex
Biological Psychiatry ( IF 9.6 ) Pub Date : 2020-12-19 , DOI: 10.1016/j.biopsych.2020.12.010
Sero Toriano Parel 1 , Catherine Jensen Peña 1
Affiliation  

Both history of early-life stress (ELS) and female sex are associated with increased risk for depression. The complexity of how ELS interacts with brain development and sex to impart risk for multifaceted neuropsychiatric disorders is also unlikely to be understood by examining changes in single genes. Here, we review an emerging literature on genome-wide transcriptional and epigenetic signatures of ELS and the potential moderating influence of sex. We discuss evidence both that there are latent sex differences revealed by ELS and that ELS itself produces latent transcriptomic changes revealed by adult stress. In instances where there are broad similarities in global signatures of ELS among females and males, genes that contribute to these patterns are largely distinct based on sex. As this area of investigation grows, an effort should be made to better understand the sex-specific impact of ELS within the human brain, specific contributions of chromosomal versus hormonal sex, how ELS alters the time course of normal transcriptional development, and the cell-type specificity of transcriptomic and epigenomic changes in the brain. A better understanding of how ELS interacts with sex to alter transcriptomic and epigenomic signatures in the brain will inform individualized therapeutic strategies to prevent or ameliorate depression and other psychiatric disorders in this vulnerable population.



中文翻译:

早年压力的全基因组特征:性别的影响

早年生活压力 (ELS) 史和女性性别都与抑郁症风险增加有关。ELS 如何与大脑发育和性别相互作用以赋予多方面神经精神疾病风险的复杂性也不太可能通过检查单个基因的变化来理解。在这里,我们回顾了关于 ELS 的全基因组转录和表观遗传特征以及性别的潜在调节影响的新兴文献。我们讨论了 ELS 揭示的潜在性别差异和 ELS 本身产生成人压力揭示的潜在转录组学变化的证据。在女性和男性的 ELS 全球特征存在广泛相似性的情况下,促成这些模式的基因在很大程度上因性别而异。随着这一调查领域的发展,应努力更好地了解 ELS 在人脑中的性别特异性影响、染色体与激素性别的特定贡献、ELS 如何改变正常转录发育的时间进程,以及转录组和表观基因组变化的细胞类型特异性在大脑中。更好地了解 ELS 如何与性相互作用以改变大脑中的转录组学和表观基因组学特征,将为个体化治疗策略提供信息,以预防或改善这一弱势群体的抑郁症和其他精神疾病。以及大脑中转录组学和表观基因组学变化的细胞类型特异性。更好地了解 ELS 如何与性相互作用以改变大脑中的转录组学和表观基因组学特征,将为个体化治疗策略提供信息,以预防或改善这一弱势群体的抑郁症和其他精神疾病。以及大脑中转录组学和表观基因组学变化的细胞类型特异性。更好地了解 ELS 如何与性相互作用以改变大脑中的转录组学和表观基因组学特征,将为个体化治疗策略提供信息,以预防或改善这一弱势群体的抑郁症和其他精神疾病。

更新日期:2020-12-19
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