Abstract

An enantioselective voltammetric sensor based on a glassy carbon electrode modified with a composite of a polyelectrolyte complex of chitosan, Carboblack C graphitized thermal carbon black, and 3,4,9,10-perylenetetracarboxylic acid is developed for the recognition and determination of tyrosine enantiomers. The enantioselectivity of the sensor is due to the formation of self-organizing chiral nanoclusters of 3,4,9,10-perylenetetracarboxylic acid. The electrochemical and analytical characteristics of the sensor are studied. The proposed sensor is used to recognize and determine L- and D-enantiomers of tyrosine in samples of urine and human blood plasma, as well as in a mixture. To increase the probability of the recognition of tyrosine enantiomers in determining them in a mixture, the chemometric method of projection to latent structures is used. It is shown that the proposed sensor ensures the determination of the ratio of L- and D-enantiomers of tyrosine in a mixture with a high probability and a relative error of less than 8%.

中文翻译：

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基于3,4,9,10-Per四甲酸复合物的伏安传感器用于酪氨酸对映体的识别和测定

摘要

开发了一种基于玻碳电极的对映选择性伏安传感器，该电极由壳聚糖的聚电解质复合物，Carboblack C石墨化热炭黑和3,4,9,10-per四甲酸的复合物改性而成，用于识别和测定酪氨酸对映体。传感器的对映选择性是由于形成了3,4,9,10-per四羧酸的自组织手性纳米团簇。研究了传感器的电化学和分析特性。拟议中的传感器用于识别和确定尿液和人血浆样品以及混合物中酪氨酸的L和D对映体。为了增加在混合物中确定酪氨酸对映体的可能性，使用了投影到潜在结构的化学计量方法。