Abstract

The fabrication of the electrode surface has been a target of investigation for several researchers trying to increase the analytical performance of electrochemical sensors. Here, the use of a trihexyltetradecylphosphonium ionic liquid functionalized multiwalled carbon nanotubes and zinc oxide nanoparticles as an active nanocomposite for the electrochemical detection of isoniazid (INZ) has been proposed for the first time. The fabricated glassy carbon electrode was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, X-ray diffraction and thermogravimetric analysis. In addition, under the optimized conditions, the proposed electrochemical sensor exhibited a synergetic effect of the multiwalled carbon nanotubes and ionic liquid anchored on its backbone, which promoted a substantial enrichment of the electrochemical oxidation of INZ. The developed sensor showed an 8-fold improvement in the differential pulse voltammetry signal carried out at pH 5 in 0.1 M phosphate buffer solution (PBS). The figures of merits were found such as linear dynamic response for INZ concentration ranging from 2 to 28 μM with detection and quantification limits of 0.012 and 0.21 μM, respectively. The applicability of the proposed electrode materials in the pharmaceutical industry was shown.

中文翻译：

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基于离子液体功能化多壁碳纳米管的简便电化学传感器用于异烟肼检测

摘要

电极表面的制造已成为试图提高电化学传感器分析性能的几位研究人员的研究目标。在这里，使用三己基十四烷基phosph离子液体官能化的多壁碳纳米管和氧化锌纳米粒子作为活性纳米复合材料，用于异烟肼（INZ）的电化学检测）是首次提出。通过傅立叶变换红外光谱，透射电子显微镜，X射线衍射和热重分析对制备的玻碳电极进行表征。此外，在最佳条件下，拟议的电化学传感器表现出多壁碳纳米管和锚定在其骨架上的离子液体的协同作用，从而促进了INZ电化学氧化的大量富集。研发的传感器在0.1 M磷酸盐缓冲溶液（PBS）中在pH 5下进行的差分脉冲伏安信号显示出8倍的改进）。发现了优点图，例如INZ浓度范围为2至28μM的线性动态响应，检出限和定量限分别为0.012和0.21μM。显示了所提出的电极材料在制药工业中的适用性。