ABSTRACT The purpose of this article is to better understand the challenges of avoiding the dark side of technological innovation. Specifically, we analyse 10 public investigations started as a reaction to a major crisis in regenerative medicine at the Karolinska Institute, Sweden, associated with the clinician-scientist Paolo Macchiarini. We interpret the reaction as an attempt to restore the balance between the stimulation and regulation of technological innovation processes by clarifying ambiguities in the regulation at the interface between research and practice. We conceptualise these ambiguities as grey zones – situations when it is unclear if the benefits of experimentation outweigh its risks – and propose that grey zones are continually created and resolved as actors in innovation governance systems counterbalance the generation of novelty and the risk of negative unintended consequences.

中文翻译：

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技术创新的灰色地带：作为对新颖性的平衡的负面意外后果

摘要本文的目的是为了更好地理解避免技术创新阴暗面的挑战。具体而言，我们分析了 10 项公众调查，这些调查是对瑞典卡罗林斯卡研究所再生医学重大危机的反应，与临床医生兼科学家 Paolo Macchiarini 相关。我们将这种反应解释为试图通过澄清研究与实践之间监管的模糊性来恢复技术创新过程的刺激和监管之间的平衡。