Still little is known about the nature of the gastrointestinal pathological alterations occurring in Parkinson’s disease (PD). Here, we used multiplexed mRNA profiling to measure the expression of a panel of 770 genes related to neuropathological processes in deep submucosal rectal biopsies of PD patients and healthy controls. Altered enteric neuropathological traits based on the expression of 22 genes related to neuroglial and mitochondrial functions, vesicle trafficking and inflammation was observed in 9 out 12 PD patients in comparison to healthy controls. These results provide new evidences that intestinal neuropathological alterations may occur in a large proportion of PD patients.

中文翻译：

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直肠活检的表达谱表明帕金森病患者肠道神经病理学特征的改变

对帕金森病 (PD) 中发生的胃肠道病理改变的性质知之甚少。在这里，我们使用多路 mRNA 分析来测量与神经病理过程相关的 770 个基因在 PD 患者和健康对照的深层粘膜下直肠活检中的表达。与健康对照相比，在 12 名 PD 患者中有 9 名观察到基于 22 个与神经胶质和线粒体功能、囊泡运输和炎症相关的基因表达的肠道神经病理学特征改变。这些结果为大部分 PD 患者可能发生肠道神经病理学改变提供了新的证据。