Goal: The importance of the main impeller design parameters in bearingless centrifugal pumps with respect to hemolysis for cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) applications are studied in this work. Methods: Impeller prototypes were designed based on theoretical principles. They were manufactured and their hydraulic and hemolytic performance were analyzed experimentally. The cell compatibility is benchmarked against commercially available centrifugal blood pumps BPX-80 (Medtronic) and FloPump 32 (International Biophysics Corporation). Results: The developed prototypes outperform the BPX-80 and FloPump 32 with regard to hemocompatibility by more than a factor of 4.5. The implemented pump features reduced overall and priming volumes. A significant improvement of the cell compatibility is achieved by increasing the radial gap between the impeller and the pump head. The blade should be sufficiently high and a blade outlet angle of 90° provides favorable performance. No correlation between the hydraulic and hemolytic performance is observed. Conclusions: This work identified the most important geometrical parameters of the impeller for blood pumps with respect to cell compatibility. This provides valuable design guidelines for improving existing pumps.

中文翻译：

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叶轮几何形状对无轴承离心泵溶血的影响

目标：在这项工作中，研究了无轴承离心泵中主要叶轮设计参数对于体外循环 (CPB) 和体外膜氧合 (ECMO) 应用溶血的重要性。方法：叶轮原型是根据理论原理设计的。它们被制造出来，并通过实验分析了它们的水力和溶血性能。细胞兼容性以市售离心血泵 BPX-80 (Medtronic) 和 FloPump 32 (International Biophysics Corporation) 为基准。结果：开发的原型在血液相容性方面优于 BPX-80 和 FloPump 32 超过 4.5 倍。实施的泵的特点是减少了总体积和启动体积。通过增加叶轮和泵头之间的径向间隙，可以显着提高电池兼容性。叶片应足够高，90° 的叶片出口角可提供良好的性能。没有观察到液压和溶血性能之间的相关性。结论：这项工作确定了血泵叶轮在细胞相容性方面最重要的几何参数。这为改进现有泵提供了有价值的设计指南。