Objective:The utility of informant-based measures of cognitive decline to accurately describe objective cognitive performance in Parkinson’s disease (PD) without dementia is uncertain. Due to the clinical relevance of this information, the purpose of this study was to examine the relationship between informant-based reports of patient cognitive decline via the Informant Questionnaire of Cognitive Decline in the Elderly (IQCODE) and objective cognition in non-demented PD controlling for cognitive status (i.e., mild cognitive impairment; PD-MCI and normal cognition; PD-NC).Method:One-hundred and thirty-nine non-demented PD participants (PD-MCI n = 38; PD-NC n = 101) were administered measures of language, executive function, attention, learning, delayed recall, visuospatial function, mood, and motor function. Each participant identified an informant to complete the IQCODE and a mood questionnaire.Results:Greater levels of informant-based responses of patient cognitive decline on the IQCODE were significantly associated with worse objective performance on measures of global cognition, attention, learning, delayed recall, and executive function in the overall sample, above and beyond covariates and cognitive status. However, the IQCODE was not significantly associated with language or visuospatial function.Conclusions:Results indicate that informant responses, as measured by the IQCODE, may provide adequate information on a wide range of cognitive abilities in non-demented PD, including those with MCI and normal cognition. Findings have important clinical implications for the utility of the IQCODE in the identification of PD patients in need of further evaluation, monitoring, and treatment.

中文翻译：

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知情人报告的认知衰退与帕金森病的客观认知表现有关

目的：基于知情人的认知衰退测量准确描述无痴呆的帕金森病 (PD) 的客观认知表现的效用尚不确定。由于这些信息的临床相关性，本研究的目的是通过老年人认知衰退知情人问卷 (IQCODE) 来检查基于知情人的患者认知衰退报告与非痴呆 PD 控制中的客观认知之间的关系用于认知状态（即轻度认知障碍；PD-MCI 和正常认知；PD-NC）。方法：139 名非痴呆 PD 参与者（PD-MCIn= 38; PD-NCn= 101) 进行了语言、执行功能、注意力、学习、延迟回忆、视觉空间功能、情绪和运动功能的测量。每个参与者都确定了一名线人来完成 IQCODE 和情绪问卷。结果：在 IQCODE 上，患者认知能力下降的更高水平的线人反应与整体认知、注意力、学习、延迟回忆、和整个样本中的执行功能，超出协变量和认知状态。然而，IQCODE 与语言或视觉空间功能没有显着相关性。结论：结果表明，由 IQCODE 测量的知情人反应可能提供有关非痴呆 PD 的广泛认知能力的足够信息，包括那些有MCI和正常认知的人。这些发现对于 IQCODE 在识别需要进一步评估、监测和治疗的 PD 患者方面的效用具有重要的临床意义。