Objective:Freezing of gait (FoG) in Parkinson’s disease (PD) has been associated with response inhibition. However, the relationship between response inhibition, neural dysfunction, and PD remains unclear. We assessed response inhibition and microstructural integrity of brain regions involved in response inhibition [right hemisphere inferior frontal cortex (IFC), bilateral pre-supplementary motor areas (preSMA), and subthalamic nuclei (STN)] in PD subjects with and without FoG and elderly controls.Method:Twenty-one people with PD and FoG (PD-FoG), 18 without FoG (PD-noFoG), and 19 age-matched controls (HC) completed a Stop-Signal Task (SST) and MRI scan. Probabilistic fiber tractography assessed structural integrity (fractional anisotropy, FA) among IFC, preSMA, and STN regions.Results:Stop-signal performance did not differ between PD and HC, nor between PD-FoG and PD-noFoG. Differences in white matter integrity were observed across groups (.001 < p < .064), but were restricted to PD versus HC groups; no differences in FA were observed between PD-FoG and PD-noFoG (p > .096). Interestingly, worse FoG was associated with higher (better) mean FA in the r-preSMA, (β = .547, p = .015). Microstructural integrity of the r-IFC, r-preSMA, and r-STN tracts correlated with stop-signal performance in HC (p ≤ .019), but not people with PD.Conclusion:These results do not support inefficient response inhibition in PD-FoG. Those with PD exhibited white matter loss in the response inhibition network, but this was not associated with FoG, nor with response inhibition deficits, suggesting FoG-specific neural changes may occur outside the response inhibition network. As shown previously, white matter loss was associated with response inhibition in elderly controls, suggesting PD may disturb this relationship.

中文翻译：

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将帕金森病患者的反应抑制、脑连接和步态冻结联系起来

目的：帕金森病（PD）患者的冻结步态（FoG）与反应抑制有关。然而，反应抑制、神经功能障碍和 PD 之间的关系仍不清楚。我们在有和没有 FoG 的 PD 受试者和老年人中评估了参与反应抑制的大脑区域的反应抑制和微结构完整性 [右半球下额叶皮层 (IFC)、双侧前补充运动区 (preSMA) 和丘脑底核 (STN)]控制方法：21 名 PD 和 FoG (PD-FoG)、18 名无 FoG (PD-noFoG) 和 19 名年龄匹配的对照 (HC) 完成了停止信号任务 (SST) 和 MRI 扫描。概率纤维束成像评估 IFC、preSMA 和 STN 区域的结构完整性（分数各向异性，FA）。结果：PD 和 HC 之间的停止信号性能没有差异，也不在 PD-FoG 和 PD-noFoG 之间。各组之间观察到白质完整性的差异（0.001 <p< .064)，但仅限于 PD相对HC组；在 PD-FoG 和 PD-noFoG 之间没有观察到 FA 差异（p> .096)。有趣的是，更差的 FoG 与 r-preSMA 中更高（更好）的平均 FA 相关，（β= .547,p= .015)。r-IFC、r-preSMA 和 r-STN 束的微结构完整性与 HC 中的停止信号性能相关。p≤ .019)，但不是 PD 患者。结论：这些结果不支持 PD-FoG 中的低效反应抑制。PD 患者在反应抑制网络中表现出白质损失，但这与 FoG 无关，也与反应抑制缺陷无关，这表明 FoG 特异性神经变化可能发生在反应抑制网络之外。如前所述，白质损失与老年对照组的反应抑制有关，表明 PD 可能会扰乱这种关系。