The exact incidence of neurological complications from coronavirus disease 2019 (COVID-19) infection remains unknown. Neurological symptoms are more common with severe form of the disease. Through neuro-invasion, the virus can affect both neurons and glial cells and induce wide range of neurological pathologies.

To systematically assess the neurological manifestations in patients diagnosed with COVID-19.

A systematic literature search of the PubMed, Scopus, and Cochrane databases was performed. Randomized controlled trials, nonrandomized controlled trials, observational studies of neurological manifestations in patients diagnosed with COVID-19.

All three-database search identified 89 publications. A total of 22 full-text articles assessed for eligibility with 12 articles excluded. Altogether, the included studies reported 290 patients with neurological manifestations. Neurological manifestations were subdivided into central causes (CNS) and peripheral causes (PNS). CNS symptoms is commoner representing 91% of all neurological patients with 9% only with PNS. Headache represented the commonest neurological symptoms in regard to number of patients, meanwhile dizziness has the highest incidence with 11.9%. Neurological manifestations were divided according to COVID-19 severity into: (1) nonsevere and (2) severe; with all CNS manifestations were more in severe patients except headache were more in nonsevere patients. All included studies were on adult patients except one study in pediatric patients with limited number of participants.

From the descriptive analyses and available data of relatively small sample-sized studies, it can be concluded that in spite of the aforementioned limitations, that a wide spectrum of neurological manifestations including CNS and PNS can occur in COVID-19 patients.

2019 年冠状病毒病 (COVID-19) 感染引起的神经系统并发症的确切发病率仍不清楚。神经系统症状在严重疾病中更为常见。通过神经侵袭，病毒可以影响神经元和神经胶质细胞，并诱发广泛的神经病理学。

系统评估诊断为 COVID-19 的患者的神经系统表现。

对 PubMed、Scopus 和 Cochrane 数据库进行了系统的文献检索。随机对照试验、非随机对照试验、诊断为 COVID-19 的患者神经系统表现的观察性研究。

所有三个数据库检索均确定了 89 种出版物。共有 22 篇全文文章符合资格评估，其中 12 篇文章被排除。纳入的研究总共报告了 290 名有神经系统表现的患者。神经系统表现分为中枢性病因（CNS）和周围性病因（PNS）。中枢神经系统症状较常见，占所有神经系统患者的 91%，其中 9% 仅有 PNS。就患者数量而言，头痛是最常见的神经症状，同时头晕的发生率最高，为 11.9%。根据COVID-19的严重程度，神经系统表现分为：（1）非严重和（2）严重；除头痛在非重症患者中较多外，所有中枢神经系统表现均在重症患者中较多。除一项针对参与者人数有限的儿童患者的研究外，所有纳入的研究均针对成年患者。

从样本量相对较小的研究的描述性分析和可用数据可以得出结论，尽管存在上述局限性，但 COVID-19 患者可能会出现包括 CNS 和 PNS 在内的广泛神经系统表现。