Muscle mass may play an important role in the metabolic profile of individuals with or without excess weight. Metabolic phenotypes classify individuals as healthy or unhealthy based on certain metabolic conditions. We investigated the association between skeletal mass indices (SMI) and the metabolically unhealthy phenotype in normal-weight and overweight/obese adults. A total of 660 adults aged 20 to 59 years were assessed by a population-based cross-sectional study. Muscle mass of the limbs or appendicular lean mass (ALM) adjusted for weight (SMIweight) and BMI (SMIBMI) was used to evaluate SMI. Logistic regression was employed to estimate the association between SMIweight, SMIBMI and metabolic phenotypes of normal-weight and overweight/obese individuals. Metabolically unhealthy individuals were older in both sexes. Metabolically unhealthy men had lower SMI values and higher fat percentage than metabolically healthy men. SMIweight was inversely associated with the metabolically unhealthy phenotype, both in normal-weight men (OR 0·49, 95 % CI 0·24, 0·99, P = 0·04) and in overweight/obese men (OR 0·32, 95 % CI 0·16, 0·64, P = 0·001). SMIBMI was inversely associated with the metabolically unhealthy phenotype in overweight/obese men (OR 0·36, 95 % CI 0·18, 0·72, P = 0·004), but not in normal-weight men (OR 0·70, 95 % CI 0·34, 1·43, P = 0·33). Among women, SMI showed no significant association with the phenotypes. In conclusion, the SMI are inversely associated with the metabolically unhealthy phenotype in men, especially among overweight/obese men.

中文翻译：

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骨骼质量指数与超重/肥胖和正常体重男性的代谢不健康表型呈负相关：一项基于人群的横断面研究

肌肉质量可能在有或没有超重的个体的代谢特征中起重要作用。代谢表型根据某些代谢条件将个体分类为健康或不健康。我们调查了正常体重和超重/肥胖成人的骨骼质量指数 (SMI) 与代谢不健康表型之间的关联。通过基于人群的横断面研究评估了总共 660 名 20 至 59 岁的成年人。四肢肌肉质量或四肢瘦体重 (ALM) 调整体重 (SMI重量) 和 BMI (SMI体重指数) 用于评估 SMI。采用逻辑回归来估计 SMI 之间的关联重量, 心电图体重指数正常体重和超重/肥胖个体的代谢表型。代谢不健康的人在男女中都比较老。代谢不健康的男性比代谢健康的男性具有更低的 SMI 值和更高的脂肪百分比。SMI重量与正常体重男性的代谢不健康表型呈负相关（OR 0·49, 95 % CI 0·24, 0·99,磷= 0·04) 和超重/肥胖男性 (OR 0·32, 95 % CI 0·16, 0·64,磷= 0·001)。SMI体重指数与超重/肥胖男性的代谢不健康表型呈负相关（OR 0·36, 95 % CI 0·18, 0·72,磷= 0·004），但在正常体重男性中没有（OR 0·70, 95 % CI 0·34, 1·43,磷= 0·33)。在女性中，SMI 与表型没有显着相关性。总之，SMI 与男性代谢不健康表型呈负相关，尤其是在超重/肥胖男性中。