Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. The pathophysiology of this virus is not very clearly known, thus, enormous efforts are being made by the scientific community to delineate its evading mechanism. In this review, we have summarized the hyperinflammation and humoral and cell-mediated immune response generated in human body after infection with the SARS-CoV-2 virus. The inflammatory response generated after infection by increased proinflammatory cytokines and chemokines, and complement proteins activation may likely contribute to disease severity. We also discussed the other factors that may affect immunity and could be important comorbidities in the disease severity and outcome.
Neuroimmunomodulation

中文翻译：

---

COVID-19 中的过度炎症和免疫反应的产生

导致 2019 年冠状病毒病 (COVID-19) 大流行的严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2) 已经影响了全世界数百万人。这种病毒的病理生理学尚不清楚，因此科学界正在付出巨大的努力来描述其逃避机制。在这篇综述中，我们总结了感染 SARS-CoV-2 病毒后人体内产生的过度炎症以及体液和细胞介导的免疫反应。感染后促炎细胞因子和趋化因子增加以及补体蛋白激活产生的炎症反应可能会导致疾病严重程度。我们还讨论了可能影响免疫力的其他因素，并且可能是疾病严重程度和结果的重要合并症。
神经免疫调节