Deciphering Human Microbiota–Host Chemical Interactions,ACS Central Science

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Deciphering Human Microbiota–Host Chemical Interactions
ACS Central Science ( IF 12.7 ) Pub Date : 2020-12-17 , DOI: 10.1021/acscentsci.0c01030
Justin E Silpe ₁ , Emily P Balskus ₁

Affiliation

Our gut harbors more microbes than any other body site, and accumulating evidence suggests that these organisms have a sizable impact on human health. Though efforts to classify the metabolic activities that define this microbial community have transformed the way we think about health and disease, our knowledge of gut microbially produced small molecules and their effects on host biology remains in its infancy. This Outlook surveys a range of approaches, hurdles, and advances in defining the chemical repertoire of the gut microbiota, drawing on examples with particularly strong links to human health. Progress toward understanding and manipulating this chemical language is being made with diverse chemical and biological expertise and could hold the key for combatting certain human diseases.

中文翻译：

破译人类微生物群与宿主的化学相互作用

我们的肠道比任何其他身体部位含有更多的微生物，并且越来越多的证据表明这些微生物对人类健康具有相当大的影响。尽管对定义该微生物群落的代谢活动进行分类的努力已经改变了我们对健康和疾病的看法，但我们对肠道微生物产生的小分子及其对宿主生物学影响的了解仍处于起步阶段。本展望调查了定义肠道微生物群化学成分的一系列方法、障碍和进展，并借鉴了与人类健康密切相关的例子。不同的化学和生物学专业知识正在理解和操纵这种化学语言方面取得进展，这可能是对抗某些人类疾病的关键。

更新日期：2021-01-27

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