Natural Biomineralization-Inspired Magnesium Silicate Composite Coating Upregulates Osteogenesis, Enabling Strong Anterior Cruciate Ligament Graft–Bone Healing In Vivo,ACS Biomaterials Science & Engineering

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Natural Biomineralization-Inspired Magnesium Silicate Composite Coating Upregulates Osteogenesis, Enabling Strong Anterior Cruciate Ligament Graft–Bone Healing In Vivo
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-12-17 , DOI: 10.1021/acsbiomaterials.0c01441
Song Shi ₁ , Wentao Fan ₁ , Ran Tao ₁ , Hua Xu ₁ , Yue Lu ₁ , Fei Han ₂ , Shuaijie Yang ₁ , Xinyu Zhou ₁ , Zhenyu Zhou ₁ , Fuyin Wan ₁

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Artificial ligaments prepared from polyethylene terephthalate (PET) are widely accepted for clinical anterior cruciate ligament (ACL) reconstruction to recover the native function of knee joints. However, due to the chemical inertness and hydrophobicity of PET, improving its bioactivity and promoting graft–bone integration are still great challenges. Inspired by the natural biomineralization process on the surface of a historical stone, in this study, a bioactive organic/inorganic composite coating that is composed of poly(allylamine hydrochloride) and chondroitin sulfate with magnesium silicate (MgSiO₃) doping is developed for surface modification of PET (MSPC-PET). This composite coating promotes adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs) and its bioactive inorganic components (MgSiO₃) could induce osteogenic differentiation of BMSCs. Furthermore, an in vivo experiment indicated that this composite coating might afford superior graft–bone integration between MSPC-PET and the host bone tunnel, and fibrous scar tissue formation was also inhibited. More importantly, a biomechanical analysis proved that there was a strong integration between the MSPC-PET graft and the bone tunnel, which will improve biomechanical properties for the restoration of ACL function. This study shows that this bioactive composite coating-modified PET graft for the ACL reconstruction can effectively achieve good integration of ACL artificial grafts and bone tunnels and prevent surgical failure.

中文翻译：

天然生物矿化作用激发的硅酸镁复合涂层可上调成骨作用，从而实现强力的前交叉韧带移植-体内修复

由聚对苯二甲酸乙二酯（PET）制成的人造韧带已广泛用于临床前交叉韧带（ACL）重建，以恢复膝关节的天然功能。但是，由于PET的化学惰性和疏水性，提高其生物活性和促进移植物-骨整合仍然是巨大的挑战。受历史石头表面自然生物矿化过程的启发，本研究中的生物活性有机/无机复合涂层由聚烯丙胺盐酸盐和硫酸软骨素与硅酸镁（MgSiO ₃）掺杂被开发用于PET（MSPC-PET）的表面改性。这种复合涂层可促进骨髓间充质干细胞（BMSC）及其生物活性无机成分（MgSiO ₃）可以诱导BMSC的成骨分化。此外，一项体内实验表明，这种复合涂层可能在MSPC-PET和宿主骨隧道之间提供优异的移植物-骨整合，并且还抑制了纤维疤痕组织的形成。更重要的是，生物力学分析证明了MSPC-PET移植物与骨隧道之间的牢固结合，这将改善恢复ACL功能的生物力学特性。这项研究表明，这种用于ACL重建的生物活性复合涂层改性PET移植物可以有效地实现ACL人造移植物与骨隧道的良好融合，并防止手术失败。

更新日期：2021-01-11

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