Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease,Immunity, Inflammation and Disease

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Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-12-17 , DOI: 10.1002/iid3.391
Yunfei Luo ₁ , Hui Lin ₁

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Low‐level of chronic inflammation activation is characteristic of obesity. Nonalcoholic fatty liver disease (NAFLD) is closely linked to obesity and is an emerging health problem, it originates from abnormal accumulation of triglycerides in the liver, and sometimes causes inflammatory reactions that could contribute to cirrhosis and liver cancer, thus its pathogenesis needs to be clarified for more treatment options. Once NAFLD is established, it contributes to systemic inflammation, the low‐grade inflammation is continuously maintained during NAFLD causing impaired resolution of inflammation in obesity, which subsequently exacerbates its severity. This study focuses on the effects of obesity‐induced inflammations, which are the underlying causes of the disease progression and development of more severe inflammatory and fibrotic stages. Understanding the relationship between obesity and NAFLD could help in establishing attractive therapeutic targets or diagnostic markers in obesity‐induced inflammation response and provides new approaches for the prevention and treatment of NAFLD in obesity.

中文翻译：

炎症引发肥胖和非酒精性脂肪肝之间的恶性循环

低水平的慢性炎症激活是肥胖的特征。非酒精性脂肪性肝病（NAFLD）与肥胖密切相关，是一个新兴的健康问题，它起源于肝脏中甘油三酯的异常积累，有时会引起炎症反应，可能导致肝硬化和肝癌，因此其发病机制需要进一步研究。澄清了更多的治疗选择。一旦 NAFLD 建立，它会导致全身炎症，在 NAFLD 期间持续维持低度炎症，导致肥胖症炎症的消退受损，从而加剧其严重程度。本研究侧重于肥胖引起的炎症的影响，这是疾病进展和更严重炎症和纤维化阶段发展的根本原因。

更新日期：2021-02-04

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