The BTLA and PD‐1 signaling pathways independently regulate the proliferation and cytotoxicity of human peripheral blood γδ T cells,Immunity, Inflammation and Disease

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The BTLA and PD‐1 signaling pathways independently regulate the proliferation and cytotoxicity of human peripheral blood γδ T cells
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-12-17 , DOI: 10.1002/iid3.390
Hyun J Hwang _{1,

2} , Jae J Lee ₁ , Sung H Kang ₃ , Jin K Suh ₃ , Eun S Choi ₃ , Seongsoo Jang ₄ , Sang-Hyun Hwang ₄ , Kyung-Nam Koh ₃ , Ho J Im ₃ , Nayoung Kim ₁

Affiliation

B‐ and T‐lymphocyte attenuator (BTLA) and programmed cell death‐1 (PD‐1) inhibit γδ T cell homeostasis and activation. This study aimed to determine whether BTLA and PD‐1 signaling pathways were convergent or independent in human peripheral blood γδ T cells. Herein we demonstrate that the signalings of BTLA and PD‐1 regulated proliferation and cytotoxicity of human γδ T cells, respectively.

中文翻译：

BTLA和PD-1信号通路独立调节人外周血γδT细胞的增殖和细胞毒性

B 和 T 淋巴细胞衰减器 (BTLA) 和程序性细胞死亡 1 (PD-1) 抑制 γδ T 细胞稳态和激活。本研究旨在确定 BTLA 和 PD-1 信号通路在人外周血 γδ T 细胞中是趋同的还是独立的。在此，我们证明 BTLA 和 PD-1 的信号分别调节人 γδ T 细胞的增殖和细胞毒性。

更新日期：2021-02-04

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