The pathogenesis of inflammatory bowel disease (IBD) has not yet been clarified and is closely related to several pro‐inflammatory factors. MicroRNA‐233 (miR‐223) might be involved in the development of IBD; however, the mechanism underlying its pathogenesis is unclear. In this study, we attempted to determine the role of miR‐223 in dextran sodium sulfate (DSS)‐induced colitis and explore the involvement of the IL‐6/STAT3 pathway in the development of intestinal mucosal inflammation.

中文翻译：

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miR-223通过抑制葡聚糖硫酸钠诱导的实验性结肠炎中的IL-6/STAT3信号通路改善肠道炎症

炎症性肠病（IBD）的发病机制尚未阐明，与多种促炎因素密切相关。MicroRNA-233 (miR-223) 可能参与 IBD 的发展；然而，其发病机制尚不清楚。在本研究中，我们试图确定 miR-223 在葡聚糖硫酸钠 (DSS) 诱导的结肠炎中的作用，并探讨 IL-6/STAT3 通路在肠粘膜炎症发展中的参与。