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Super enhancers—Functional cores under the 3D genome
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-12-17 , DOI: 10.1111/cpr.12970
Juqing Zhang 1 , Wei Yue 1 , Yaqi Zhou 2 , Mingzhi Liao 2 , Xingqi Chen 3 , Jinlian Hua 1
Affiliation  

Complex biochemical reactions take place in the nucleus all the time. Transcription machines must follow the rules. The chromatin state, especially the three-dimensional structure of the genome, plays an important role in gene regulation and expression. The super enhancers are important for defining cell identity in mammalian developmental processes and human diseases. It has been shown that the major components of transcriptional activation complexes are recruited by super enhancer to form phase-separated condensates. We summarize the current knowledge about super enhancer in the 3D genome. Furthermore, a new related transcriptional regulation model from super enhancer is outlined to explain its role in the mammalian cell progress.

中文翻译:


超级增强子——3D基因组下的功能核心



复杂的生化反应始终在细胞核中发生。转录机器必须遵守规则。染色质状态,特别是基因组的三维结构,在基因调控和表达中发挥着重要作用。超级增强子对于确定哺乳动物发育过程和人类疾病中的细胞身份非常重要。已经表明,转录激活复合物的主要成分被超级增强子募集以形成相分离的缩合物。我们总结了目前关于 3D 基因组超级增强子的知识。此外,还概述了超级增强子的一种新的相关转录调控模型,以解释其在哺乳动物细胞进展中的作用。
更新日期:2020-12-17
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