Improved metrics of Post-traumatic stress disorder (PTSD) treatment response that extend beyond a focus on symptom reduction to incorporate meaningful, patient-centred indicators of functioning are needed in veteran populations. The aim of this study was to extend previous research by investigating whether indicators of functioning can successfully distinguish against symptom response categories derived from the Post-Traumatic Stress Disorder Checklist (PCL-5) pre- and post- PTSD treatment. Participants were 472 veterans receiving hospital-based treatment for PTSD. In addition to the PCL-5, measures included quality of life, social relationships, physical health and psychological distress. Four mutually exclusive, progressive response categories were used to define treatment response including: No Response, Response, Response and Below Threshold, and Remission. PTSD symptom reductions were associated with corresponding improvements in broader indicators of functioning. However, it was only when the magnitude of symptom reduction placed the individual in the ‘Response and Below Threshold’ category that improvement on functioning measures achieved levels indicative of a good end state. Traditional metrics of treatment ‘response’ in PTSD treatment do not necessarily indicate recovery on important functioning indicators. Only when an individual both responds to treatment and drops below threshold for probable disorder are they likely to report having meaningful levels of functioning.

中文翻译：

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定义退伍军人的创伤后应激障碍恢复：根据功能指标对症状变化进行基准测试

退伍军人群体需要改进的创伤后应激障碍 (PTSD) 治疗反应指标，这些指标不仅限于减轻症状，还需要纳入有意义的、以患者为中心的功能指标。本研究的目的是通过调查功能指标是否可以成功区分来自创伤后应激障碍检查表 (PCL-5) 前后 PTSD 治疗的症状反应类别，从而扩展先前的研究。参与者是 472 名因 PTSD 接受医院治疗的退伍军人。除了 PCL-5，衡量标准还包括生活质量、社会关系、身体健康和心理困扰。四个相互排斥的渐进反应类别用于定义治疗反应，包括：无反应、反应、反应和低于阈值，和缓解。PTSD 症状的减轻与更广泛的功能指标的相应改善有关。然而，只有当症状减轻的程度将个人置于“反应和低于阈值”类别时，功能措施的改善才能达到表明良好最终状态的水平。PTSD 治疗中治疗“反应”的传统指标不一定表明重要功能指标的恢复。只有当一个人对治疗有反应并且低于可能的疾病阈值时，他们才可能报告具有有意义的功能水平。只有当症状减轻的程度将个人置于“反应和低于阈值”类别时，功能措施的改善才能达到表明良好最终状态的水平。PTSD 治疗中治疗“反应”的传统指标不一定表明重要功能指标的恢复。只有当一个人对治疗有反应并且低于可能的疾病阈值时，他们才可能报告具有有意义的功能水平。只有当症状减轻的程度将个人置于“反应和低于阈值”类别时，功能措施的改善才能达到表明良好最终状态的水平。PTSD 治疗中治疗“反应”的传统指标不一定表明重要功能指标的恢复。只有当一个人对治疗有反应并且低于可能的疾病阈值时，他们才可能报告具有有意义的功能水平。