Interleukin‐32 (IL‐32) is a pro‐inflammatory cytokine that induces other cytokines involved in inflammation, including tumour necrosis factor (TNF)‐α, IL‐6 and IL‐1β. Recent evidence suggests that IL‐32 has a crucial role in host defence against pathogens, as well as in the pathogenesis of chronic inflammation. Abnormal IL‐32 expression has been linked to several autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel diseases, and a recent study suggested the importance of IL‐32 in the pathogenesis of type 1 diabetes. However, despite accumulating evidence, many molecular characteristics of this cytokine, including the secretory route and the receptor for IL‐32, remain largely unknown. In addition, the IL‐32 gene is found in higher mammals but not in rodents. In this review, we outline the current knowledge of IL‐32 biological functions, properties, and its role in autoimmune diseases. We particularly highlight the role of IL‐32 in rheumatoid arthritis and type 1 diabetes.

中文翻译：

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白细胞介素32在自身免疫中的作用

白细胞介素32（IL-32）是一种促炎性细胞因子，可诱导参与炎症的其他细胞因子，包括肿瘤坏死因子（TNF）-α，IL-6和IL-1β。最新证据表明，IL‐32在宿主抵抗病原体以及慢性炎症的发病机理中起着至关重要的作用。IL-32的异常表达与多种自身免疫性疾病有关，例如类风湿性关节炎和炎症性肠病，最近的一项研究表明IL-32在1型糖尿病的发病机理中具有重要意义。但是，尽管有越来越多的证据，但这种细胞因子的许多分子特征，包括分泌途径和IL-32受体，仍是未知之数。此外，IL-32基因存在于高等哺乳动物中，但不在啮齿动物中。在这篇评论中 我们概述了IL-32生物学功能，特性及其在自身免疫性疾病中的作用的当前知识。我们特别强调了IL‐32在类风湿关节炎和1型糖尿病中的作用。