A 22% increase in Staphylococcus aureus colonization was observed in Norwegian recruits during first year of military service. The aim was to determine whether specific genotypes caused the increase and to examine carriage status based on genotyping. Characterization of S. aureus from nose, throat and perineum sampled at enrolment and discharge included spa typing, MLVA, detection of PVL genes and antimicrobial susceptibility testing. spa typing demonstrated high and stable genetic diversity. The three most frequent spa types were found in 15% of recruits at enrolment and in 29% at discharge. Only t084 increased significantly (p = 0.02). Subtyping revealed that t084, t065 and t002 consisted of 13, 6 and 11 different MLVA types, respectively, at discharge. The military cohort (n = 265) consisted of S. aureus carriers of identical genotype (n = 99, 38%), carriers of non‐identical genotype (n = 52, 20%), intermittent carriers (n = 86, 33%) and non‐carriers (n = 27, 10%). Carrier status was indefinable for one recruit due to unavailable isolates for genotyping. Antibiotic resistance towards erythromycin, fusidic acid and clindamycin increased significantly and above national surveillance levels. The observed increase in S. aureus colonization during military service was caused by many different genotypes implying many transmission routes. Genotype did not correlate with colonization niche or carriage status.

中文翻译：

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服兵役期间金黄色葡萄球菌定植增加是由特定基因型引起的吗？一项前瞻性队列研究中长期携带的分子检查

在服兵役的第一年，挪威新兵中金黄色葡萄球菌定植增加了22％。目的是确定特定基因型是否引起了增加，并根据基因分型检查运输状态。在入院和出院时从鼻子，喉咙和会阴采集的金黄色葡萄球菌的特征包括水疗分型，MLVA，PVL基因检测和抗菌药敏试验。水疗分型显示出高度稳定的遗传多样性。三种最常见的水疗中心入学时有15％的新兵发现了这类病毒，出院时发现了29％的病毒。只有t084显着增加（p = 0.02）。分型显示，t084，t065和t002在放电时分别包含13、6和11种不同的MLVA类型。军人队列（n = 265）包括相同基因型的金黄色葡萄球菌携带者（n = 99，38％），不相同的基因型的携带者（n = 52，20％），间歇性携带者（n = 86，33％ ）和非运营商（n = 27，10％）。由于无法获得基因分型的隔离株，一位新兵的携带者状态无法确定。对红霉素，夫西地酸和克林霉素的抗生素耐药性显着提高，超过了国家监测水平。观察到的金黄色葡萄球菌增加服兵役期间的殖民化是由许多不同的基因型引起的，这些基因型意味着许多传播途径。基因型与定居位或运输状态不相关。