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New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC–MS and NMR based molecular characterization
Journal of King Saud University-Science ( IF 3.7 ) Pub Date : 2020-12-18 , DOI: 10.1016/j.jksus.2020.101289
Areej Mohammad Al-Taweel , Shagufta Perveen , Saleh Ibrahim Alqasoumi , Raha Orfali , Hanan Y. Aati , Shahnaz , Ebtesam Nasser Alsultan , Bandar Alghanem , Hayat Shaibah

Plicosepalus curviflorus is distributed in Africa, Yemen and Saudi Arabia and applied to treat cancer, tonsillitis, otitis media and for curing diabetes. The objective of this study is to isolate chemical constituents from this medicinally important plant and it yielded one undescribed gallocatechin derivative 1 along with nine known compounds 210. In this study, the metabolite profiling of n-butanol fraction of P. curviflorus was also measured by using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOf-MS). Our research provided the facts for the theory that this plant is a good source of flavane and flavonoids and can be used as medicine. This application allowed to unambiguously identify eight compounds 1118 from n-butanol soluble fraction of P. curviflorus. We describe here complete characterization of one new compound isolated from the n-butanol soluble fraction of P. curviflorus by NMR and ESI-MS. To the best of our good grasp, compounds 1215, represents the example of substituted catechin derivatives identified by LC-QTOf-MS method.



中文翻译:

通过LC-MS和基于NMR的分子鉴定,从非洲/阿拉伯药用植物Plicosepalus curviflorus的空中部分获得了新的黄烷没食子酸酯

Plicosepalus curviflorus分布于非洲,也门和沙特阿拉伯,用于治疗癌症,扁桃体炎,中耳炎和治疗糖尿病。本研究的目的是分离化学成分从该药用重要的植物和它产生一个未描述的没食子儿茶素衍生物1与九个已知化合物沿着2 - 10。在这项研究中,弯曲体育丁醇级分的代谢物谱还通过使用液相色谱-四极杆飞行时间质谱(LC-QTOf-MS)进行测量。我们的研究为这一理论提供了事实,即该植物是黄烷和类黄酮的良好来源,可以用作药物。该应用程序可以从可弯曲的丁醇的丁醇可溶性馏分中明确鉴定出8种化合物1118。我们在这里描述了一种新的化合物的完整表征,该化合物是通过NMR和ESI-MS从弯曲紫假单胞菌丁醇可溶级分中分离出来的。尽我们所能,化合物1215代表通过LC-QTOf-MS方法鉴定的取代儿茶素衍生物的实例。

更新日期:2020-12-27
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