Owing in part to the implications of resurgence for issues surrounding human health and adaptive problem solving, a substantial amount of laboratory research has been dedicated to understanding why this form of relapse occurs and what factors affect it. This research, however, has never been extended to mice, leaving unknown the specific experimental parameters that are appropriate for studying resurgence in this species. Two experiments were conducted in which mice were exposed to a three-phase resurgence preparation in a multiple-baseline-across-subjects design. In Phase 1, pressing a target lever produced food according to a variable-interval 15-s schedule. In Phase 2, target-lever pressing was extinguished, and nose poking produced reinforcement according to either a variable-interval 15-s (Experiment 1) or fixed-ratio 1 (Experiment 2) schedule. Finally, alternative reinforcement was suspended to test for resurgence. Lever pressing relapsed for one of four mice in Experiment 1, but all four mice demonstrated relapse in Experiment 2. Thus, relatively dense schedules of alternative reinforcement may be required to reliably study resurgence of previously reinforced responding in mice. These findings are instructive for researchers who are interested in studying resurgence of mice’s behavior and further demonstrate the cross-species generality of this form of relapse.

部分原因是复活对围绕人类健康和适应性问题解决的问题的影响，因此大量的实验室研究致力于了解为什么会出现这种形式的复发以及哪些因素会影响这种复发。但是，这项研究从未扩展到小鼠，尚不清楚适合于研究该物种中的死灰复燃的特定实验参数。进行了两个实验，其中小鼠在多基线交叉受试者设计中暴露于三相回潮制剂。在阶段1中，按下目标杆会按照15秒的可变间隔时间表生产食物。在第2阶段，目标控制杆的压力消失了，鼻戳根据可变间隔15秒（实验1）或固定比率1（实验2）的时间表产生了增强作用。最后，替代加固被暂停以测试复苏。在实验1中，四只小鼠中的一只复发了杠杆压迫，但在实验2中，四只小鼠全部复发。因此，可能需要相对密集的替代强化方案以可靠地研究小鼠中先前强化的应答的复发。这些发现对于有兴趣研究小鼠行为复发的研究人员具有指导意义，并进一步证明了这种复发形式的种间通用性。但是所有四只小鼠在实验2中均表现出复发。因此，可能需要相对密集的替代强化方案以可靠地研究小鼠中先前强化的应答的复发。这些发现对于有兴趣研究小鼠行为复发的研究人员具有指导意义，并进一步证明了这种复发形式的种间通用性。但所有四只小鼠在实验2中均表现出复发。因此，可能需要相对密集的替代强化方案以可靠地研究小鼠中先前强化的应答的复发。这些发现对于有兴趣研究小鼠行为复发的研究人员具有指导意义，并进一步证明了这种复发形式的种间通用性。