The conceptualization and empirical knowledge base related to major depression has increased dramatically in recent years. We now have well-developed and validated models of depression from a range of theoretical perspectives. These models have significantly enhanced the development of effective treatments and preventative interventions. Although various prevention programs are available, Web-based protocols can enhance accessibility to evidence-based prevention programs. The current study involved a randomized controlled trial focused on the prevention and treatment of depression in high-risk first- and second-year undergraduate students. Three Internet-delivered preventative programs were compared: cognitive behavioral therapy (CBT; MoodGym), attentional bias modification, and an active attentional control condition. Participants (n = 350) completed symptom measurement pre- and post-intervention (6 weeks) and again at a 4-month follow-up, when they were also administered a structured diagnostic interview. Participants in the CBT condition showed more dramatic and continuous depressive symptom improvement between baseline and follow-up than did participants in the other two conditions. In addition, significantly fewer individuals in CBT condition met diagnostic criteria for major depression at follow-up than in the other conditions. These findings have important implications for future early intervention research and practice.

中文翻译：

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互联网提供的CBT和注意力偏倚调整对抑郁症的早期干预的随机对照试验

近年来，与重性抑郁症有关的概念化和经验知识基础急剧增加。现在，我们已从一系列理论角度开发并验证了抑郁症模型。这些模型大大增强了有效治疗和预防性干预的发展。尽管可以使用各种预防程序，但是基于Web的协议可以增强对基于证据的预防程序的可访问性。目前的研究涉及一项随机对照试验，该试验的重点是高危一，二年级本科生抑郁症的预防和治疗。比较了三种Internet提供的预防程序：认知行为疗法（CBT; MoodGym），注意偏见调整和积极的注意控制条件。参与者（n = 350）在干预前和干预后（6周）完成症状测量，并在4个月的随访中再次完成症状测量，同时还接受了结构化的诊断性访谈。与其他两个条件下的参与者相比，CBT条件下的参与者在基线和随访之间表现出更为显着和持续的抑郁症状改善。另外，与其他情况相比，处于CBT状态的患者在随访时符合严重抑郁症诊断标准的人数要少得多。这些发现对未来的早期干预研究和实践具有重要意义。与其他两个条件下的参与者相比，CBT条件下的参与者在基线和随访之间表现出更为显着和持续的抑郁症状改善。另外，与其他情况相比，处于CBT状态的患者在随访时符合严重抑郁症诊断标准的人数要少得多。这些发现对未来的早期干预研究和实践具有重要意义。与其他两个条件下的参与者相比，CBT条件下的参与者在基线和随访之间表现出更为显着和持续的抑郁症状改善。另外，与其他情况相比，处于CBT状态的患者在随访时符合严重抑郁症诊断标准的人数要少得多。这些发现对未来的早期干预研究和实践具有重要意义。