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Highly sensitive antimonene-coated black phosphorous-based surface plasmon-resonance biosensor for DNA hybridization: design and numerical analysis
Journal of Nanophotonics ( IF 1.5 ) Pub Date : 2020-12-17 , DOI: 10.1117/1.jnp.14.046015
Maneesh Kumar Singh 1 , Sarika Pal 1 , Alka Verma 2 , Yogendra Kumar Prajapati 3 , Jai Prakash Saini 4
Affiliation  

Abstract. The design of an ultrasensitive surface plasmon resonance (SPR) sensor for the detection of deoxyribose nucleic acid (DNA) hybridization is highly desirable for biomedical applications. We have proposed an SPR sensor architecture (Prism-SF10/Al/Si/BP/Antimonene/phosphate buffer saline solution) and performed its numerical analysis for DNA hybridization using angular interrogation at 633 nm. Antimonene is used as a biorecognition element layer for better attachment of single stranded (ss), i.e., ss probe DNA on its surface, due to its higher binding energy for ssDNA (even greater than graphene). Silicon and black phosphorous are utilized to enhance the electromagnetic field at the sensing layer interface. Aluminum is used as an surface plasmon active metal and it also improves the quality factor. Remarkable sensitivity (202.37 deg / refractive index unit) is attained for this work, which is greater than any other SF10 prism-based SPR sensor proposed to date. The performance of the SPR biosensor is meticulously evaluated as limit-of-detection (0.0028 nM) and figure-of-merit (0.037 nM − 1) with respect to the concentration of complementary target ssDNA in the sensing medium. This versatile biosensor shows great application to detect deadly diseases via DNA hybridization in the biomedical field if developed as an SPR chip for experimental verification.

中文翻译:

用于 DNA 杂交的高灵敏度锑烯涂层黑磷表面等离子体共振生物传感器:设计和数值分析

摘要。用于检测脱氧核糖核酸 (DNA) 杂交的超灵敏表面等离子体共振 (SPR) 传感器的设计对于生物医学应用是非常理想的。我们提出了一种 SPR 传感器架构(Prism-SF10/Al/Si/BP/锑烯/磷酸盐缓冲盐溶液),并使用 633 nm 的角度询问对 DNA 杂交进行了数值分析。锑烯被用作生物识别元件层,以更好地附着单链 (ss),即在其表面上的 ss 探针 DNA,因为它对 ssDNA 的结合能更高(甚至大于石墨烯)。硅和黑磷​​用于增强传感层界面处的电磁场。铝被用作表面等离子体活性金属,它也提高了品质因数。卓越的灵敏度 (202. 37 度 / 折射率单位)是为这项工作获得的,这比迄今为止提出的任何其他基于 SF10 棱镜的 SPR 传感器都大。SPR 生物传感器的性能被仔细评估为检测限 (0.0028 nM) 和品质因数 (0.037 nM - 1),相对于传感介质中互补目标 ssDNA 的浓度。如果开发为 SPR 芯片进行实验验证,这种多功能生物传感器在生物医学领域通过 DNA 杂交检测致命疾病的应用非常广泛。037 nM - 1) 相对于传感介质中互补目标 ssDNA 的浓度。如果开发为 SPR 芯片进行实验验证,这种多功能生物传感器在生物医学领域通过 DNA 杂交检测致命疾病的应用非常广泛。037 nM - 1) 相对于传感介质中互补目标 ssDNA 的浓度。如果开发为 SPR 芯片进行实验验证,这种多功能生物传感器在生物医学领域通过 DNA 杂交检测致命疾病的应用非常广泛。
更新日期:2020-12-17
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