Background COVID-19 has caused great concern for patients with underlying medical conditions. We aimed to determine the prognosis of patients with current or previous cancer with either a PCR-confirmed COVID-19 infection or a probable diagnosis according to chest CT scan. Methods We conducted a case control study in a referral hospital on confirmed COVID-19 adult patients with and without a history of cancer from February 25th to April 21st , 2020. Patients were matched according to age, gender, and underlying diseases including ischemic heart disease (IHD), diabetes mellitus (DM), and hypertension (HTN). Demographic features, clinical data, comorbidities, symptoms, vital signs, laboratory findings, and chest computed tomography (CT) images have been extracted from patients’ medical records. Multivariable logistic regression was used to estimate odd ratios and 95% confidence intervals of each factor of interest with outcomes. Results Fifty-three confirmed COVID-19 patients with history of cancer were recruited and compared with 106 non-cancerous COVID-19 patients as controls. Male to female ratio was 1.33 and 45% were older than 65. Dyspnea and fever were the most common presenting symptoms in our population with 57.86 and 52.83% respectively. Moreover, dyspnea was significantly associated with an increased rate of mortality in the cancer subgroup ( p = 0.013). Twenty-six patients (49%) survived among the cancer group while 89 patients (84%) survived in control ( p = 0.000). in cancer group, patients with hematologic cancer had 63% mortality while patients with solid tumors had 37%. multivariate analysis model for survival prediction showed that history of cancer, impaired consciousness level, tachypnea, tachycardia, leukocytosis and thrombocytopenia were associated with an increased risk of death. Conclusion In our study, cancer increased the mortality rate and hospital stay of COVID-19 patients and this effect remains significant after adjustment of confounders. Compared to solid tumors, hematologic malignancies have been associated with worse consequences and higher mortality rate. Clinical and para-clinical indicators were not appropriate to predict death in these patients.

中文翻译：

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患有 COVID-19 和癌症病史的住院患者的临床特征、结果和死亡风险因素：倾向评分匹配研究


背景 COVID-19 引起了患有基础疾病的患者的高度关注。我们的目的是确定当前或既往癌症患者的预后，这些患者要么是 PCR 确诊的 COVID-19 感染，要么是根据胸部 CT 扫描得出的可能诊断。方法 我们于2020年2月25日至4月21日在一家转诊医院对确诊的有或无癌症病史的COVID-19成年患者进行了病例对照研究。根据年龄、性别和基础疾病（包括缺血性心脏病）对患者进行匹配（IHD）、糖尿病（DM）和高血压（HTN）。从患者的病历中提取了人口统计学特征、临床数据、合并症、症状、生命体征、实验室检查结果和胸部计算机断层扫描 (CT) 图像。使用多变量逻辑回归来估计每个感兴趣因素与结果的奇数比和 95% 置信区间。结果 招募了 53 名有癌症病史的确诊 COVID-19 患者，并与 106 名非癌症 COVID-19 患者作为对照进行比较。男女比例为1.33，其中45%年龄在65岁以上。呼吸困难和发烧是我们人群中最常见的症状，分别占57.86%和52.83%。此外，呼吸困难与癌症亚组死亡率增加显着相关（p = 0.013）。癌症组中有 26 名患者 (49%) 存活，而对照组有 89 名患者 (84%) 存活 (p = 0.000)。在癌症组中，血液癌患者的死亡率为63%，而实体瘤患者的死亡率为37%。 生存预测的多变量分析模型表明，癌症病史、意识水平受损、呼吸急促、心动过速、白细胞增多和血小板减少与死亡风险增加相关。结论 在我们的研究中，癌症增加了 COVID-19 患者的死亡率和住院时间，并且在调整混杂因素后，这种影响仍然显着。与实体瘤相比，血液恶性肿瘤具有更严重的后果和更高的死亡率。临床和副临床指标不适合预测这些患者的死亡。