As an alternative to pharmacological treatment to diseases, lifestyle interventions, such as dietary changes and physical activities, can help maintain healthy metabolic conditions. Recently, the emerging analyses of volatile organic compounds (VOCs) from breath and short-chain fatty acids (SCFAs) from plasma/feces have been considered as useful tools for the diagnosis and mechanistic understanding of metabolic diseases. Furthermore, diet-induced changes of SCFAs in individuals with diagnosed metabolic abnormalities have been correlated with the composition changes of the gut microbiome. More interestingly, the analysis of exhaled breath (breathomics) has gained attention as a useful technique to measure the human VOC profile altered as a result of dietary interventions. In this mini-review, we examined recent clinical trials that performed promising dietary interventions, SCFAs analysis in plasma/feces, and VOC profile analysis in exhaling breath to understand the relationship between dietary intervention and metabolic health.

作为疾病药物治疗的替代方法，生活方式干预，如饮食改变和体育活动，可以帮助维持健康的代谢状况。最近，对呼吸中的挥发性有机化合物 (VOC) 和血浆/粪便中的短链脂肪酸 (SCFA) 的新兴分析已被认为是诊断和了解代谢疾病的有用工具。此外，在被诊断为代谢异常的个体中，饮食引起的 SCFA 变化与肠道微生物组的组成变化相关。更有趣的是，呼出气（呼吸组学）的分析作为一种有用的技术来测量因饮食干预而改变的人体 VOC 分布而受到关注。在这个迷你评论中，