Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials,ACS Biomaterials Science & Engineering

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Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-12-16 , DOI: 10.1021/acsbiomaterials.0c01291
Benjamin Cossette ₁ , Sean H. Kelly ₁ , Joel H. Collier ₁

Affiliation

Intranasal vaccines offer key advantages over traditional needle-based vaccines. They are simple to administer and painless and establish local immunity at mucosal surfaces. Owing to these advantages, they are particularly attractive for use in resource-limited locations of the world. Subunit vaccines also have advantages for global distribution, as they can be engineered to be more stable to fluctuations in environmental conditions than live-attenuated or inactivated vaccines, but they tend to be poorly immunogenic intranasally. Toward realizing the potential of intranasal subunit vaccination, biomaterial-based technologies are emerging. This review provides an overview of recent progress in the preclinical development of biomaterial-based intranasal vaccines against subunit antigens and should serve as an effective introduction to the current state of this exciting field. We provide a brief overview of the obstacles facing intranasal vaccine development and identify key design criteria for consideration when designing biomaterials for intranasal subunit vaccine delivery. Promising strategies are discussed across a wide array of biomaterial classes, with a focus on selected exemplary works that highlight the considerable potential of intranasal vaccines and the biomaterial-based technologies that enable them.

中文翻译：

采用纳米材料和生物材料的鼻内亚单位疫苗接种策略

与传统的基于针头的疫苗相比，鼻内疫苗具有关键优势。它们易于管理且无痛，可在粘膜表面建立局部免疫力。由于这些优点，它们特别适合在世界资源有限的地区使用。亚单位疫苗还具有全球分布的优势，因为它们可以被设计成比减毒活疫苗或灭活疫苗对环境条件的波动更稳定，但它们在鼻内的免疫原性往往较差。为了实现鼻内亚单位疫苗接种的潜力，基于生物材料的技术正在兴起。这篇综述概述了针对亚单位抗原的基于生物材料的鼻内疫苗的临床前开发的最新进展，并应作为这一激动人心领域的当前状态的有效介绍。我们提供了鼻内疫苗开发面临的障碍的简要概述，并确定了设计鼻内亚单位疫苗递送生物材料时要考虑的关键设计标准。在广泛的生物材料类别中讨论了有前途的策略，重点是精选的示范性工作，这些工作突出了鼻内疫苗的巨大潜力以及支持它们的基于生物材料的技术。我们提供了鼻内疫苗开发面临的障碍的简要概述，并确定了设计鼻内亚单位疫苗递送生物材料时要考虑的关键设计标准。在广泛的生物材料类别中讨论了有前途的策略，重点是精选的示范性工作，这些工作突出了鼻内疫苗的巨大潜力以及支持它们的基于生物材料的技术。我们提供了鼻内疫苗开发面临的障碍的简要概述，并确定了设计鼻内亚单位疫苗递送生物材料时要考虑的关键设计标准。在广泛的生物材料类别中讨论了有前途的策略，重点是精选的示范性工作，这些工作突出了鼻内疫苗的巨大潜力以及支持它们的基于生物材料的技术。

更新日期：2020-12-16

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