ABSTRACT

In this paper we report the analysis of essential oils from the woods of C. libani and P. pinea and from the berries of J. excelsa. Several differences were observed with respect to previous studies. In particular, the wood of C. libani was mainly characterized by sesquiterpenes with himachalenes isomers, (E)- and (Z)-α-atlantones and α-acorenol (7.0%) as most representative compounds; in P. pinea wood oil and J. excelsa berries oil were observed differences mainly among the minor components with different isomers of some specific compounds not previously recognized. The oils were assessed in selected bioactivity tests. C. libani wood oil resulted the most active in both the antioxidant and cytotoxic (against human A375 malignant melanoma, human MDA-MB 231 breast adenocarcinoma and human HCT116 colon carcinoma cell lines) tests; on the other hand in the antimicrobial assay it was observed a different susceptibility of different bacteria to the different oils. All the oils exerted a remarkable activity against the yeast Candida albicans. Taken together, these results support some of the traditional uses of these three plants in the Mediterranean area and give evidence of their potential on an industrial level.

摘要

在本文中，我们报告了来自利比亚松（C. libani）和菠萝松（P. pinea）的木材以及excelsa的浆果精油的分析。与先前的研究相比，观察到一些差异。特别地，所述木材C. libani主要特征在于与himachalenes异构体，（倍半萜烯ë） -和（Ž）-α-atlantones和α-acorenol（7.0％），为最有代表性的化合物; 在P. pinea木油和J. excelsa浆果油中观察到的差异主要是次要组分之间的差异，这些组分具有某些以前未认识到的特定化合物的不同异构体。在选定的生物活性测试中对油进行了评估。C. libani木油在抗氧化剂和细胞毒性（针对人类A375恶性黑色素瘤，人类MDA-MB 231乳腺腺癌和人类HCT116结肠癌细胞系）测试中产生的活性最高；另一方面，在抗菌测定中，观察到不同细菌对不同油脂的敏感性不同。所有的油对酵母白色念珠菌都有显着的活性。综上所述，这些结果支持了这三种植物在地中海地区的一些传统用途，并提供了它们在工业水平上的潜力的证据。