Abstract

Phytochemical studies led to the isolation of five new sesquiterpeniod esters, named balsamiferine N-R, along with ten known compounds (6-15) from the leaves of Blumea balsamifera (L.) DC. The skeletons of nine known sesquiterpeniods belong to guaiane and eudesmane. The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic analysis, and quantum-chemical electronic circular dichroism (ECD) calculation. Compounds 3 and 4 showed significant inhibitory effects on influenza A virus (H3N2) with IC₅₀ values of 46.23 μg/mL and 38.49 μg/mL, respectively. It was the first report on the anti-influenza A virus constituents from B. balsamifera.

摘要

植物化学研究导致从Blumea balsamifera（L.）DC的叶子中分离出五种新的倍半萜烯酯，称为balsamiferine NR，以及十种已知化合物（6-15）。九种已知的倍半萜的骨骼分别属于guaiane和eudesmane。通过全面的光谱分析和量子化学电子圆二色性（ECD）计算，阐明了新化合物的结构，包括其绝对构型。化合物3和4对甲型流感病毒（H3N2）表现出明显的抑制作用，IC ₅₀值分别为46.23μg/ mL和38.49μg/ mL。这是关于Balsamifera抗甲型流感病毒成分的第一份报告。