Abstract

Chemical investigations of the 75% EtOH extract from the fruits of Crataegus pinnatifida led to the isolation of three undescribed naturally occurring sesquineolignans with two 8-O-4'-type neolignan moieties, cratapinnatifidas A-C (1–3). Their chemical structures were elucidated by the comprehensive spectroscopic analyses (HRESIMS, 1D and 2D-NMR). In the bioactivity assay, their cytotoxic activities against two human hepatoma cell lines (HepG2 and Hep3B) were evaluated and no significant activity was seen with IC₅₀ values ranging from 12.5 to 50.0 μM.

中文翻译：

---

山楂果的三个新的五倍体

摘要

从果实的75％乙醇提取物的化学调查山楂导致三个隔离未描述的天然存在的sesquineolignans具有两个8- ö -4'-型新木脂素结构部分，cratapinnatifidas AC（1 - 3）。通过全面的光谱分析（HRESIMS，1D和2D-NMR）阐明了它们的化学结构。在生物活性测定中，评估了它们对两种人肝癌细胞系（HepG2和Hep3B）的细胞毒性活性，未观察到明显的活性，IC ₅₀值为12.5至50.0μM。