A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher’s method, and LC–MS analysis. The characterized compounds’ biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.

中文翻译：

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木瓜木瓜的化学成分及其生物学活性

通过色谱方法，从木瓜的细枝中分离出一种新的巨型石楠型去甲倍半萜苷糖苷（1），并与其中的11种已知植物化学物质分离。通过常规的1D和2D NMR数据分析，ECD实验，水解反应以及改进的Mosher方法和LC-MS分析，确定了新分离株1的化学结构。评价了表征化合物的生物学效应，包括对癌细胞系的细胞毒性，抗神经炎活性和潜在的神经营养作用。