Cortical spreading depression aggravates early brain injury in a mouse model of subarachnoid hemorrhage,Journal of Biophotonics

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Cortical spreading depression aggravates early brain injury in a mouse model of subarachnoid hemorrhage
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-12-17 , DOI: 10.1002/jbio.202000379
Yue Tang ₁ , Deyuan She ₂ , Pengcheng Li ₃ , Li Pan ₂ , Jinling Lu ₃ , Peng Liu ₄

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Cortical spreading depression (CSD) has been observed during the early phase of subarachnoid hemorrhage (SAH). However, the effect of CSD on the cerebral blood flow (CBF) and cerebral oxyhemoglobin (CHbO) during the early phase of SAH has not yet been assessed directly. We, therefore, used laser speckle imaging and optical intrinsic sinal imaging to record CBF and CHbO during CSD and cerebral cortex perfusion (CCP) at 24 hours after CSD in a mouse model of SAH. SAH was induced by blood injection into the prechiasmatic cistern. When CSD occurred, the change trend of CBF and CHbO in Sham group and SAH group was the same, but ischemia and hypoxia in SAH group was more significant. At 24 hours after SAH, the CCP of CSD group was lower than that of no CSD group, and the neurological function score of CSD group was lower. We conclude that induction of CSD further aggravates cerebral ischemia and worsens neurological dysfunction in the early stage of experimental SAH. Our study underscores the consequence of CSD in the development of early brain injury after SAH.

中文翻译：

在蛛网膜下腔出血的小鼠模型中，皮质扩散性抑郁症加重了早期脑损伤

在蛛网膜下腔出血（SAH）的早期阶段就观察到了皮质扩散抑制（CSD）。但是，尚未直接评估CSD对SAH早期的脑血流量（CBF）和脑氧合血红蛋白（CHbO）的影响。因此，在SAH小鼠模型中，我们使用激光散斑成像和光学内在正弦成像来记录CSD和CSD后24小时的大脑皮层灌注（CCP）期间的CBF和CHbO。SAH是通过将血液注射入前交叉蓄水池来诱导的。当发生CSD时，Sham组和SAH组的CBF和CHbO变化趋势相同，但SAH组的缺血和缺氧更为明显。SAH后24小时，CSD组的CCP低于无CSD组，而CSD组的神经功能评分较低。我们得出结论，在实验性SAH的早期阶段，CSD的诱导会进一步加重脑缺血并加重神经功能障碍。我们的研究强调了CSD在SAH后早期脑损伤发展中的后果。

更新日期：2020-12-17

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