Advances in Base‐Mediated Post‐Ugi Transformations via Peptidyl Anion Trapping,Asian Journal of Organic Chemistry

当前位置： X-MOL 学术 › Asian J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Advances in Base‐Mediated Post‐Ugi Transformations via Peptidyl Anion Trapping
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-12-16 , DOI: 10.1002/ajoc.202000648
Anirban Ghoshal _{1,

2} , Mayur D. Ambule _{1,

2} , Anamika Yadav _{1,

2} , Ajay Kumar Srivastava _{1,

2}

Affiliation

Advances in base‐mediated post‐Ugi transformations are reported and discussed. The minireview encompasses reports showing the abstraction of an alpha proton adjacent to amide carbonyl in aldehyde‐derived Ugi adducts under basic conditions to perform intramolecular and intermolecular cyclizations. The methodologies have been broadly classified depending on the peptidyl anion trapping under metal‐free, metal‐catalyzed, microwave‐assisted, and external electrophile‐aided reaction conditions. A comprehensive analysis of the methods has been presented, highlighting the importance in synthetic and medicinal chemistry.

中文翻译：

通过肽基阴离子捕集在碱介导的Ugi后转化中的进展

报道并讨论了碱基介导的Ugi后转化的进展。小型审查涵盖了一些报告，这些报告显示了在碱性条件下，在醛衍生的Ugi加合物中与酰胺羰基相邻的α质子的抽象，以进行分子内和分子间环化。根据在无金属，金属催化，微波辅助和亲电辅助反应条件下捕获的肽基阴离子，对方法进行了大致分类。提出了对方法的全面分析，突出了在合成化学和药物化学中的重要性。

更新日期：2021-02-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11