Purpose

Vitamin D (Vit D), as an immunomodulator, has been hypothesized to play a critical role in the pathogenesis of endometriosis. Thus, in this study, we evaluated whether there is an association between 25-hydroxyvitamin D [25(OH)D] and susceptibility to endometriosis in Iranian women.

Methods

Women at reproductive age, including 56 healthy women and 54 patients with endometriosis, were enrolled in the study. Serum levels of 25(OH)D, calcium, parathyroid hormone (PTH), and peritoneal fluid (PF) levels of 25(OH)D were assessed.

Results

The serum and PF levels of 25(OH)D in the patients with endometriosis were significantly lower than the control group (P = 0.001 and P = 0.03, respectively). Subjects with serum levels of 25(OH)D lower than 20 ng/mL had a 2.7 times higher risk of endometriosis than people with 25(OH)D serum levels higher than 20 ng/mL (non-deficient) (OR = 2.7, 95 % confidence interval: 1.24−5.80, P = 0.01). The serum levels of calcium and PTH were significantly lower and higher in patients with endometriosis compared with controls, respectively (P < 0.001, P = 0.02, respectively). Also, the serum levels of 25(OH)D were lower in stages I-II endometriosis than stage III-IV; however, no significant difference was observed.

Conclusion

Our findings showed that people with Vit D deficiency are at higher risk of endometriosis.

中文翻译：

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维生素 D 缺乏是伊朗女性子宫内膜异位症的危险因素

目的

维生素 D (Vit D) 作为一种免疫调节剂，已被假设在子宫内膜异位症的发病机制中起关键作用。因此，在本研究中，我们评估了 25-羟基维生素 D [25(OH)D] 与伊朗女性子宫内膜异位症的易感性之间是否存在关联。

方法

该研究招募了育龄妇女，包括 56 名健康妇女和 54 名子宫内膜异位症患者。评估血清 25(OH)D、钙、甲状旁腺激素 (PTH) 和腹膜液 (PF) 水平的 25(OH)D。

结果

子宫内膜异位症患者血清和PF水平的25(OH)D显着低于对照组（分别为P =0.001和P =0.03）。血清 25(OH)D 水平低于 20 ng/mL 的受试者患子宫内膜异位症的风险是 25(OH)D 血清水平高于 20 ng/mL（非缺乏）的受试者的 2.7 倍（OR = 2.7， 95% 置信区间：1.24−5.80，P = 0.01）。与对照组相比，子宫内膜异位症患者血清钙和 PTH 水平分别显着降低和升高（分别为P < 0.001，P = 0.02）。此外，I-II 期子宫内膜异位症的血清 25(OH)D 水平低于 III-IV 期；然而，没有观察到显着差异。

结论

我们的研究结果表明，缺乏维生素 D 的人患子宫内膜异位症的风险更高。