Progressive liver fibrosis may result in cirrhosis, portal hypertension and increased risk of hepatocellular carcinoma. We performed a meta-analysis to compare liver fibrosis staging in chronic liver disease patients using 2-D shear wave elastography (2-D SWE) and point shear wave elastography (pSWE). The PubMed, Web of Science and Cochrane Library databases were searched until May 31, 2020 for studies evaluating the diagnostic performance of 2-D SWE and pSWE in assessing liver fibrosis. Pooled sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratios and area under receiver operating characteristic curve were estimated using the bivariate random effects model. As a result, 71 studies with 11,345 patients were included in the analysis. The pooled sensitivities of 2-D SWE and pSWE significantly differed for the detection of significant fibrosis (F ≥ 2; 0.84 vs. 0.76, p < 0.001) and advanced fibrosis (F ≥ 3; 0.90 vs. 0.83, p = 0.003), but not for detection of cirrhosis (F = 4; 0.89 vs. 0.85, p = 0.090). The pooled specificities of 2-D SWE and pSWE did not significantly differ for detection of F ≥ 2 (0.81 vs. 0.79, p = 0.753), F ≥ 3 (0.87 vs. 0.83, p = 0.163) or F = 4 (0.87 vs. 0.84, p = 0.294). Both 2-D SWE and pSWE have high sensitivity and specificity for detecting each stage of liver fibrosis. Two-dimensional SWE has higher sensitivity than pSWE for detection of significant fibrosis and advanced fibrosis.

进行性肝纤维化可能导致肝硬化、门脉高压和肝细胞癌风险增加。我们进行了一项荟萃分析，以使用二维剪切波弹性成像 (2-D SWE) 和点剪切波弹性成像 (pSWE) 比较慢性肝病患者的肝纤维化分期。直到 2020 年 5 月 31 日，PubMed、Web of Science 和 Cochrane 图书馆数据库都被搜索了评估 2-D SWE 和 pSWE 在评估肝纤维化方面的诊断性能的研究。使用双变量随机效应模型估计汇总的敏感性、特异性、阳性和阴性似然比、诊断优势比和接受者操作特征曲线下的面积。结果，包含 11,345 名患者的 71 项研究被纳入分析。p < 0.001）和晚期纤维化（F ≥ 3；0.90 vs. 0.83，p  = 0.003），但不用于检测肝硬化（F = 4；0.89 vs. 0.85，p  = 0.090）。2-D SWE 和 pSWE 的汇总特异性在检测 F ≥ 2（0.81 对 0.79，p  = 0.753）、F ≥ 3（0.87 对 0.83，p  = 0.163）或 F = 4（0.87与 0.84，p  = 0.294）。2-D SWE 和 pSWE 对于检测肝纤维化的各个阶段都具有高灵敏度和特异性。在检测显着纤维化和晚期纤维化方面，二维 SWE 比 pSWE 具有更高的灵敏度。