Molecular farming intends to use crop plants as biofactories for high value-added compounds following application of a wide range of biotechnological tools. In particular, the conversion of nonfood crops into efficient biofactories is expected to be a strong asset in the development of a sustainable bioeconomy. The ‘nonfood’ status combined with the high metabolic versatility and the capacity of high-yield cultivation highlight the plant genus Nicotiana as one of the most appropriate ‘chassis’ for molecular farming. Nicotiana species are a rich source of valuable industrial, active pharmaceutical ingredients and nutritional compounds, synthesized from highly complex biosynthetic networks. Here, we review and discuss approaches currently used to design enriched Nicotiana species for molecular farming using new plant breeding techniques (NPBTs).

分子农业旨在应用多种生物技术工具后，利用农作物作为高附加值化合物的生物工厂。特别是，将非粮食作物转化为高效的生物工厂预计将成为可持续生物经济发展的重要资产。 “非食品”地位与高代谢多功能性和高产栽培能力相结合，突出了烟草属植物作为分子农业最合适的“底盘”之一。烟草物种是有价值的工业活性药物成分和营养化合物的丰富来源，由高度复杂的生物合成网络合成。在这里，我们回顾并讨论了目前使用新植物育种技术（NPBT）设计用于分子农业的丰富烟草物种的方法。