Marine mussels have attracted attention in the last years due to their incredible ability to stick to various organic and inorganic substrates in harsh environments. This capacity has been attributed to specific proteins secreted by marine mussels, known as marine mussel adhesive proteins (MAPs). These proteins have in their constitution an unusual amino acid, 3,4-dihydroxyphenylalanine (DOPA).

Many efforts have been made to produce materials with adhesive properties equivalent to those shown by MAPs for biomedical applications. Therefore, distinct polymeric biomaterials, either with two-dimensional or three-dimensional structures, have been developed trying to mimic this incredible adhesive performance.

In this review, an overview of the application of MAPs and their adhesive properties on the development of distinct biomaterials based on both natural and synthetic polymers will be presented, namely on films and hydrogels production. The variety of biomedical applications of these bioinspired materials will be also discussed.

近年来，由于海洋贻贝具有在恶劣环境中粘附各种有机和无机基质的强大能力，因此备受关注。这种能力归因于海洋贻贝分泌的特定蛋白质，称为海洋贻贝粘附蛋白（MAPs）。这些蛋白质在结构上具有不寻常的氨基酸3,4-二羟基苯丙氨酸（DOPA）。

已经做出了许多努力来生产具有与MAPs相同的粘合性能的材料，用于生物医学应用。因此，已经开发出具有二维或三维结构的独特的聚合物生物材料，以试图模仿这种难以置信的粘合性能。

在这篇综述中，将概述MAPs的应用及其在基于天然和合成聚合物的独特生物材料开发中的粘合性能，即薄膜和水凝胶的生产。这些生物启发材料的各种生物医学应用也将进行讨论。