Xanthones are important chemical class of bioactive products that confers therapeutic benefits. Of several xanthones, mangiferin is known to be distributed widely across several fruits, vegetables and medicinal plants. Mangiferin has been shown to exert neuroprotective effects in both in-vitro and in-vivo models. Mangiferin attenuates cerebral infarction, cerebral edema, lipid peroxidation (MDA), neuronal damage, etc. Mangiferin further potentiate levels of endogenous antioxidants to confer protection against the oxidative stress inside the neurons. Mangiferin is involved in the regulation of various signaling pathways that influences the production and levels of proinflammatory cytokines in brain. Mangiferin cosunteracted the neurotoxic effect of amyloid-beta, MPTP, rotenone, 6-OHDA etc and confer protection to neurons. These evidence suggested that the mangiferin may be a potential therapeutic strategy for the treatment of various neurological disorders. The present review demonstrated the pharmacodynamics-pharmacokinetics of mangiferin and neurotherapeutic potential in several neurological disorders with underlying mechanisms.

氧杂蒽酮是重要的化学类生物活性产品，具有治疗功效。在几种氧杂蒽酮中，已知芒果苷广泛分布于多种水果、蔬菜和药用植物中。芒果苷已在体外和体内模型中显示出神经保护作用。芒果苷减轻脑梗塞、脑水肿、脂质过氧化 (MDA)、神经元损伤等。芒果苷进一步增强内源性抗氧化剂的水平，以保护神经元内部的氧化应激。芒果苷参与各种信号通路的调节，这些信号通路影响大脑中促炎细胞因子的产生和水平。芒果苷协同β-淀粉样蛋白、MPTP、鱼藤酮、6-OHDA 等的神经毒性作用并赋予神经元保护作用。这些证据表明芒果苷可能是治疗各种神经系统疾病的潜在治疗策略。本综述证明了芒果苷的药效学-药代动力学和具有潜在机制的几种神经系统疾病的神经治疗潜力。