Breast cancer is the most common and significant cancers in females regarding the loss of life quality. Similar to other cancers, one of the etiologic factors in breast cancer is DNA damage. A plethora of molecules are responsible for sensing DNA damage and mediating actions which lead to DNA repair, senescence, cell cycle arrest and if damage is unbearable to apoptosis. In each of these, aberrations leading to unrepaired damage was resulted in uncontrolled proliferation and cancer. Another cellular function is autophagy defined as a process eliminating of unnecessary proteins in stress cases involved in pathogenesis of cancer. Knowing their role in cancer, scholars have tried to develop strategies in order to target DDR and autophagy. Further, the interactions of DDR and autophagy plus their regulatory role on each other have been focused simultaneously. The present review study has aimed to illustrate the importance of DDR and autophagy in breast cancer according to the related studies and uncover the relation between DDR and autophagy and its significance in breast cancer therapy.

乳腺癌是女性中最常见和最严重的癌症，会影响生活质量。与其他癌症类似，乳腺癌的病因之一是 DNA 损伤。过多的分子负责感知 DNA 损伤并介导导致 DNA 修复、衰老、细胞周期停滞以及如果损伤无法忍受细胞凋亡的作用。在每一个中，导致未修复损伤的畸变导致不受控制的增殖和癌症。另一种细胞功能是自噬，定义为在涉及癌症发病机制的应激情况下消除不必要蛋白质的过程。了解它们在癌症中的作用后，学者们试图制定策略以针对 DDR 和自噬。更远，DDR 和自噬的相互作用以及它们对彼此的调节作用已被同时关注。本综述旨在根据相关研究阐明DDR和自噬在乳腺癌中的重要性，并揭示DDR与自噬之间的关系及其在乳腺癌治疗中的意义。