Several animal studies have showed the beneficial effects of physical exercise (PE) on brain function and health. Alzheimer’s Disease (AD) is the most common type of dementia, characterized by the presence of aggregated extracellular amyloid-beta (Aβ) and neurofibrillary tangles, with progressive cognitive decline. Therapeutic approaches such as PE showed to be effective in halting AD progression. Here, we present a systematic review about PE and AD. The search was carried out using the PubMed and LILACS databases. The following keywords were used: Alzheimer; PE; animal model. All found studies adopted aerobic exercise training as the PE protocol (100%). We identified running on treadmill as the most commonly used PE routine (62.5%). The duration of each session, intensity, frequency, and period of training most used were 60 min/day (62.5%), moderate intensity (87.5%), 5 days/week (62.5%), and 4 (37.5%) or 12 (37.5%) weeks, respectively. The AD animal models most used were the Tg APP/PS1ΔE9 (25%), models based on i.c.v. infusion of AβOs (25%) and streptozotocin (25%). All protocols used rodents to their experiments (100%), but mice were the most common (62.5%). Finally, the main results presented in all studies were capable to reduce significantly AD consequences, such as reducing Aβ or pro-inflammatory proteins levels (100%). The lack of resistance training protocols in animal models of AD indicates a huge gap that should be investigated in future studies. We suggest that PE protocols must be adapted according to the specie, lineage and life span of the animal.

多项动物研究表明，体育锻炼 (PE) 对大脑功能和健康有益。阿尔茨海默病 (AD) 是最常见的痴呆类型，其特征是存在聚集的细胞外淀粉样蛋白 (Aβ) 和神经原纤维缠结，并伴有进行性认知能力下降。治疗方法如 PE 显示可有效阻止 AD 进展。在这里，我们提出了关于 PE 和 AD 的系统评价。使用 PubMed 和 LILACS 数据库进行搜索。使用了以下关键词：阿尔茨海默病；聚乙烯；动物模型。所有发现的研究都采用有氧运动训练作为 PE 方案 (100%)。我们确定在跑步机上跑步是最常用的体育锻炼 (62.5%)。每次训练的持续时间、强度、频率和最常用的训练时间为 60 分钟/天 (62.5%)、中等强度 (87.5%)、5 天/周 (62.5%) 和 4 (37.5%) 或 12 (37.5%) 周。最常用的 AD 动物模型是 Tg APP/PS1ΔE9 (25%)，基于 AβOs (25%) 和链脲佐菌素 (25%) icv 输注的模型。所有方案都使用啮齿动物进行实验 (100%)，但小鼠是最常见的 (62.5%)。最后，所有研究中呈现的主要结果都能够显着减少 AD 后果，例如降低 Aβ 或促炎蛋白水平 (100%)。AD 动物模型中缺乏阻力训练方案表明存在巨大的差距，应在未来的研究中进行调查。我们建议必须根据动物的种类、血统和寿命来调整 PE 协议。