Parkinson’s disease (PD) is characterized by gradual neurodegeneration and forfeiture of dopamine neurons in substantia nigra pars compacta which ultimately leads to depletion of dopamine levels. PD patients not only display motor features such as rigidity, tremor, and bradykinesia but also non-motor features such as depression, anxiety, etc. Various treatments are available for PD patients such as dopamine replacement are well established but it is only partially or transiently effective. As these therapies not able to restore dopaminergic neurons and delay the development of Parkinson’s disease, therefore, the need for an effective therapeutic approach is crucial. The present review discusses a comprehensive overview of current novel targets for PD which includes molecular chaperone, neuroinflammation, mitochondrial dysfunction, neuromelanin, Ubiquitin-proteasome system, protein Abelson, Synaptic vesicle glycoprotein 2C, and Cocaine-amphetamine-regulated transcript, etc. These approaches will help to identify new targets for the treatment of disease and may provide a ray of hope for PD patient treatment.

帕金森病 (PD) 的特征是逐渐神经变性和黑质致密部中多巴胺神经元的丧失，最终导致多巴胺水平的消耗。PD 患者不仅表现出强直、震颤和运动迟缓等运动特征，还表现出抑郁、焦虑等非运动特征。 PD 患者可用的各种治疗方法如多巴胺替代疗法已成熟，但只是部分或暂时性的有效的。由于这些疗法无法恢复多巴胺能神经元并延缓帕金森病的发展，因此，对有效治疗方法的需求至关重要。本综述讨论了当前 PD 新靶点的全面概述，包括分子伴侣、神经炎症、线粒体功能障碍、神经黑色素、