Necrotic enteritis (NE) is being considered as one of the most important intestinal diseases in the recent poultry production systems, which causes huge economic losses globally. NE is caused by Clostridium perfringens, a pathogenic bacterium, and normal resident of the intestinal microflora of healthy broiler chickens. Gastrointestinal tract (GIT) of broiler chicken is considered as the most integral part of pathogen’s entrance, their production and disease prevention. Interaction between C. perfringens and other pathogens such as Escherichia coli and Salmonella present in the small intestine may contribute to the development of NE in broiler chickens. The antibiotic therapy was used to treat the NE; however European Union has imposed a strict ban due to the negative implications of drug resistance. Moreover, antibiotic growth promoters cause adverse effects on human health as results of withdrawal of antibiotic residues in the chicken meat. After restriction on use of antibiotics, numerous studies have been carried out to investigate the alternatives to antibiotics for controlling NE. Thus, possible alternatives to prevent NE are bio-therapeutic agents (Probiotics), prebiotics, organic acids and essential oils which help in nutrients digestion, immunity enhancement and overall broiler performance. Recently, probiotics are extensively used alternatives to antibiotics for improving host health status and making them efficient in production. The aim of review is to describe a replacement to antibiotics by using different microbial strains as probiotics such as bacteria and yeasts etc. having bacteriostatic properties which inhibit growth of pathogens and neutralize the toxins by different modes of action.

在最近的家禽生产系统中，坏死性肠炎（NE）被认为是最重要的肠道疾病之一，在全球造成巨大的经济损失。NE是由产气荚膜梭菌（Clostridium perfringens）引起的，它是一种致病性细菌，是健康肉鸡肠道菌群的正常居民。肉鸡的胃肠道（GIT）被认为是病原体进入，其产生和疾病预防的最重要部分。产气荚膜梭菌与其他病原体如大肠杆菌和沙门氏菌之间的相互作用小肠中存在的蛋白质可能有助于肉鸡NE的发展。用抗生素治疗NE。然而，由于耐药性的负面影响，欧盟已实施了严格的禁令。而且，抗生素生长促进剂由于鸡肉中残留的抗生素残留而对人体健康产生不利影响。在限制使用抗生素之后，已经进行了许多研究来研究用于控制NE的抗生素替代品。因此，预防NE的可能替代方法是生物治疗剂（益生菌），益生元，有机酸和精油，它们有助于营养物质的消化，增强免疫力和提高肉鸡的整体性能。最近，益生菌是抗生素的广泛替代品，可改善宿主的健康状况并提高生产效率。综述的目的是描述通过使用不同的微生物菌株作为益生菌如细菌和酵母菌等来替代抗生素，所述细菌具有抑菌特性，其通过不同的作用方式抑制病原体的生长并中和毒素。