Abstract

Wound dressing materials should be biocompatible, bactericidal, porous and mechanically strong. Moreover, the use of cost-effective and environmentally friendly materials is also important for developing wound dressing materials. However, developing scaffolds with all desired properties remains challenging. Herein, we have developed a porous polyacrylonitrile (PPAN) membrane modified by silver nanoparticles (AgNPs) with mussel-inspired polydopamine (PDA) assistance. Polydopamine (PDA) assisted in coating the antibacterial AgNPs uniformly in a size-controlled manner. Additionally, physiochemical properties such as the hydrophilicity and mechanical properties of the PAN membrane were enhanced. The resulting antibacterial membrane was tested for biocompatibility and antibacterial properties. The results showed that the AgNPs-functionalized membrane was biocompatible with fibroblast cells and had bactericidal effects on both gram-positive and gram-negative bacteria. In summary, this paper presents an approach for improving the physiochemical properties of cost-effective electrospun PAN membranes together with biocompatibility and targeted antibacterial properties.

摘要

伤口敷料应具有生物相容性，杀菌性，多孔性和机械强度。此外，使用成本有效且环保的材料对于开发伤口敷料也很重要。然而，开发具有所有期望特性的支架仍然具有挑战性。在这里，我们已经开发出了一种多孔聚丙烯腈（PPAN）膜，该膜由贻贝启发的聚多巴胺（PDA）辅助的银纳米颗粒（AgNPs）改性。聚多巴胺（PDA）有助于以尺寸控制的方式均匀地涂覆抗菌AgNP。另外，增强了PAN膜的物理化学性质如亲水性和机械性质。测试所得的抗菌膜的生物相容性和抗菌性能。结果表明，AgNPs官能化膜与成纤维细胞具有生物相容性，并且对革兰氏阳性和革兰氏阴性细菌均具有杀菌作用。总而言之，本文提出了一种提高成本效益的电纺PAN膜的物理化学性能以及生物相容性和靶向抗菌性能的方法。