Abstract

Purpose

Lowered thiol (-SH) groups and glutathione (GSH) metabolism may be associated with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). The objectives of this study were to systematically review and meta-analyze the associations among -SH groups, GSH, GSH peroxidase (GPx), GSH reductase (GR), and GSH transferase (GST) and PCa/BPH.

Methods

Four electronic databases were searched for studies that reported -SH and GSH variables in PCa/BPH and healthy controls (HC) and the data were meta-analyzed by calculating Hedges’s g with 95% confidence intervals.

Results

Twenty studies were included in this meta-analysis. Total -SH (g = −1.750, −2.341/−1.159), GPx (g = −0.789, −1.234/−0.344), GSH (g = −2.219, −4.132/−0.305), and the combination of -SH, GPx, and GSH (g = −1.271, −1.271/−0.800) were significantly lower in PCa patients than in HC. -SH (g = −1.752, −3.123/−0.381) and the combination of -SH, GPx, and GSH (g = −0.813, −1.298/−0.327) were significantly lower in BPH patients than in HC. GPx was significantly lower in PCa than in BPH patients (g = −0.455, −0.896/−0.014). Heterogeneity levels were very high, but Egger’s test showed that none of the biomarkers showed significant publication bias.

Conclusion

Thiol/GPx antioxidant defenses are significantly attenuated in patients with PCa while patients with BPH occupy an intermediate risk group position between PCa patients and HC.

中文翻译：

---

降低前列腺癌中硫醇，谷胱甘肽和谷胱甘肽过氧化物酶的水平：一项荟萃分析研究

摘要

目的

硫醇（-SH）组和谷胱甘肽（GSH）代谢降低可能与前列腺癌（PCa）和良性前列腺增生（BPH）有关。这项研究的目的是系统地审查和荟萃分析-SH组，GSH，GSH过氧化物酶（GPx），GSH还原酶（GR）和GSH转移酶（GST）和PCa / BPH之间的关联。

方法

在四个电子数据库中搜索了报告PCa / BPH和健康对照（HC）中-SH和GSH变量的研究，并通过以95％置信区间计算Hedges's g对数据进行了荟萃分析。

结果

这项荟萃分析包括二十项研究。总计-SH（g = -1.750，-2.341 / -1.159），GPx（g = -0.789，-1.234 / -0.344），GSH（g = -2.219，-4.132 / -0.305），-SH的组合PCa患者的，GPx和GSH（g = −1.271，−1.271 / −0.800）显着低于HC。BPH患者的-SH（g = -1.752，-3.123 / -0.381）以及-SH，GPx和GSH的组合（g = -0.813，-1.298 / -0.327）显着低于HC。PCa中的GPx显着低于BPH患者（g = -0.455，-0.896 / -0.014）。异质性水平很高，但是Egger的测试表明，没有任何生物标志物显示出明显的出版偏倚。

结论

PCa患者的Thiol / GPx抗氧化剂防御能力显着减弱，而BPH患者则在PCa患者和HC之间处于中等风险组。