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A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma‐like features and Nuclear Clusters (DGONC)
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2021-01-12 , DOI: 10.1111/nan.12680
Jessica C Pickles 1, 2 , Kshitij Mankad 3 , Miren Aizpurua 4 , Simon Ml Paine 5 , Leslie R Bridges 6 , Fernando Carceller 7 , Elwira Szychot 7 , Mark Walker 8 , Amy R Fairchild 1, 2 , Talisa Mistry 2 , Olumide Ogunbiyi 2 , Alice Rolland 9 , Thomas J Stone 1, 2 , Carryl Dryden 10 , Dilys Addy 10 , Elisa Garimberti 10 , Jane Chalker 10 , Felix Sahm 11, 12, 13 , David Tw Jones 11, 14 , Darren Hargrave 1, 15 , Thomas S Jacques 1, 2
Affiliation  

We read with interest Deng et al.'s recent manuscript concerning a newly molecularly defined glioneuronal CNS tumour entity, termed diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC)(1). DGONCs were identified by a distinctive methylation profile that segregated away from previously recognised molecular groups of CNS tumours. On further review, the authors describe DGONCs as a novel glioneuronal tumour with key neuropathological features including oligodendroglioma-like perinuclear halos and nuclear clusters.

中文翻译:

具有少突胶质细胞瘤样特征和核簇(DGONC)的弥漫性胶质神经元肿瘤病例系列

我们感兴趣地阅读了 Deng 等人最近关于一种新的分子定义的胶质神经元 CNS 肿瘤实体的手稿,称为具有少突胶质细胞瘤样特征和核簇 (DGONC)(1) 的弥漫性胶质神经元肿瘤。DGONCs 是通过一种独特的甲基化谱来鉴定的,该谱与先前识别的 CNS 肿瘤分子组分离。在进一步回顾中,作者将 DGONCs 描述为一种具有关键神经病理学特征的新型胶质神经元肿瘤,包括少突胶质细胞瘤样核周晕和核簇。
更新日期:2021-01-12
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