Ameliorative effect of persimmon (Diospyros kaki) in cognitively impaired diabetic mice,Journal of Food Biochemistry

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Ameliorative effect of persimmon (Diospyros kaki) in cognitively impaired diabetic mice
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-12-16 , DOI: 10.1111/jfbc.13581
Eun Jin Shin ₁ , Jong Min Kim ₁ , Jin Yong Kang ₁ , Seon Kyeong Park ₁ , Hye Ju Han ₁ , Hyun-Jin Kim ₁ , Chul-Woo Kim ₂ , Uk Lee ₂ , Ho Jin Heo ₁

Affiliation

The effects of ethanolic extract of Diospyros kaki (EED) on diabetic cognitive impairment were investigated in high‐fat diet (HFD)‐induced mouse. After HFD was fed to mouse for 16 weeks, EED was administrated to mouse for 4 weeks. EED reduced fasting blood glucose level and improved cognitive and behavioral dysfunction. EED improved serum biomarkers related to lipid and liver damage better than positive control (PC). In addition, EED ameliorated impaired cholinergic system, increased oxidative stress as well as mitochondrial dysfunction compared with HFD group. In the molecular study, EED downregulated the phosphorylation of c‐Jun N‐terminal kinase (p‐JNK), which phosphorylates the serine residue of insulin receptor substrate‐1 (IRS‐1pSer). Finally, various physiological compounds such as tannin‐based ingredients were identified using UPLC‐QTOF/MS². These results suggest that EED can help improve cognitive impairment caused by HFD.

中文翻译：

柿（Diospyros kaki）对认知障碍糖尿病小鼠的改善作用

的乙醇提取物的影响柿树（EED）在高脂饮食（HFD）诱导的小鼠中研究了糖尿病认知障碍。将HFD喂食小鼠16周后，将EED给予小鼠4周。EED降低了空腹血糖水平，改善了认知和行为功能障碍。EED改善了与脂质和肝损害相关的血清生物标志物，优于阳性对照（PC）。此外，与HFD组相比，EED改善了胆碱能系统受损，氧化应激增加以及线粒体功能障碍。在分子研究中，EED下调了c-Jun N末端激酶（p-JNK）的磷酸化，该磷酸化了胰岛素受体底物1（IRS-1pSer）的丝氨酸残基。最后，使用UPLC-QTOF / MS ²鉴定了各种生理化合物，例如基于单宁的成分。这些结果表明，EED可以帮助改善由HFD引起的认知障碍。

更新日期：2021-01-19

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