Bioassay‐guided isolation of anti‐inflammatory constituents from Celtis sinensis leaves,Journal of Food Biochemistry

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Bioassay‐guided isolation of anti‐inflammatory constituents from Celtis sinensis leaves
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-12-16 , DOI: 10.1111/jfbc.13580
Zhipeng Qi _{1,

2} , Xianying Fang _{1,

2} , Yingying Xie _{1,

2} , Lei Wang _{1,

2} , Yiwei Zhang _{1,

2} , Linguo Zhao _{1,

2}

Affiliation

Ginkgo acids (GAs) in ginkgo products usually lead to allergies or liver toxicity. In this study, the GA‐induced toxicity was attenuated and Con A‐induced T‐lymphocyte proliferation was inhibited by extracts of Celtis sinensis leaves (ECSL). So, the active ingredients in ECSL were studied to solve the problems caused by GAs. First, the eight components of MeOH extracts were determined by HPLC‐DAD/LC‐MS. Then, the 12 active ingredients were separated based on the anti‐inflammatory activity. Lymphocyte conversion showed that the inhibition rates of apigenin, quercetin, and isovitexin at 100 μM on Con A‐activated proliferation of T cells were up to 82.46%, 62.86% and 42.76%, respectively. The inhibition rate on the LPS‐induced NO release in RAW 264.7 cells of quercetin, apigenin, isovitexin, and vitexin were exceeding 80% at 100 μM. Taken together, the material foundation for the screen of GAs toxicity‐attenuated ingredients were provided here.

更新日期：2021-01-19

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